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Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein.

作者信息

Yan Y C, Bai Y, Wang L F, Miao S Y, Koide S S

机构信息

Shanghai Institute of Cell Biology, Academia Sinica, China.

出版信息

Proc Natl Acad Sci U S A. 1990 Apr;87(7):2405-8. doi: 10.1073/pnas.87.7.2405.

DOI:10.1073/pnas.87.7.2405
PMID:1690887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC53697/
Abstract

A rat testis lambda gt11 cDNA library was screened with a monoclonal antibody raised against a human sperm membrane protein designated YWK-II. A clone was found with a cDNA insert composed of 1837 base pairs that contained an open reading frame coding for 191 amino acid residues. The deduced polypeptide contained a segment with high homology to the transmembrane-cytoplasmic domains of the A4 amyloid protein found in brain plaques of Alzheimer disease patients. A sequence of basic amino acid residues, Arg-Lys-Arg, was found instead of Lys-Lys-Lys at the probable membrane-cytoplasmic junction that may be a unique property of sperm membrane proteins.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b4/53697/d8c68fcb25e9/pnas01032-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b4/53697/d8c68fcb25e9/pnas01032-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/04b4/53697/d8c68fcb25e9/pnas01032-0031-a.jpg

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本文引用的文献

1
Membrane proteins: the amino acid composition of membrane-penetrating segments.膜蛋白：膜穿透片段的氨基酸组成。
Eur J Biochem. 1981 Nov;120(2):275-8. doi: 10.1111/j.1432-1033.1981.tb05700.x.
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Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62. doi: 10.1073/pnas.89.22.10758.
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Intracellular protein topogenesis.细胞内蛋白质拓扑结构生成
Proc Natl Acad Sci U S A. 1980 Mar;77(3):1496-500. doi: 10.1073/pnas.77.3.1496.
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Monoclonal antibody inducing human sperm agglutination.
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Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.阿尔茨海默病：一种新型脑血管淀粉样蛋白的纯化与特性的初步报告
Biochem Biophys Res Commun. 1984 May 16;120(3):885-90. doi: 10.1016/s0006-291x(84)80190-4.
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Identification of antigen in rat spermatogenic cells interacting with an anti-human sperm monoclonal antibody.鉴定大鼠生精细胞中与抗人精子单克隆抗体相互作用的抗原。
Biol Reprod. 1987 Sep;37(2):467-77. doi: 10.1095/biolreprod37.2.467.
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Properties of a monoclonal antibody interacting with human sperm.
Arch Androl. 1987;18(3):245-54. doi: 10.3109/01485018708988490.
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Identification in rodents and other species of an mRNA homologous to the human beta-amyloid precursor.
Brain Res. 1988 Jun;427(3):293-7. doi: 10.1016/0169-328x(88)90052-6.
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Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.编码脑血管和神经炎性斑块淀粉样肽的cDNA的分子克隆与特性分析。
Proc Natl Acad Sci U S A. 1987 Jun;84(12):4190-4. doi: 10.1073/pnas.84.12.4190.