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Heart of darkness: the downside of trastuzumab.

作者信息

Hayes Daniel F, Picard Michael H

出版信息

J Clin Oncol. 2006 Sep 1;24(25):4056-8. doi: 10.1200/JCO.2006.07.5143. Epub 2006 Aug 14.

DOI:10.1200/JCO.2006.07.5143
PMID:16908930
Abstract
摘要

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Heart of darkness: the downside of trastuzumab.黑暗之心：曲妥珠单抗的弊端
J Clin Oncol. 2006 Sep 1;24(25):4056-8. doi: 10.1200/JCO.2006.07.5143. Epub 2006 Aug 14.
2
Trastuzumab trials steal show at ASCO meeting.曲妥珠单抗试验在ASCO会议上抢尽风头。
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3
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the M.D. Anderson Cancer Center experience.曲妥珠单抗在转移性乳腺癌中的长期心脏耐受性：MD安德森癌症中心的经验
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4
Trastuzumab faces trials, clinical and otherwise.曲妥珠单抗面临着各种试验，包括临床试验及其他方面的试验。
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Bevacizumab and heart failure risk in patients with breast cancer: a thorn in the side?贝伐单抗与乳腺癌患者的心力衰竭风险：棘手问题？
J Clin Oncol. 2011 Feb 20;29(6):603-6. doi: 10.1200/JCO.2010.32.9060. Epub 2011 Jan 4.
6
Troponin I as a predictor for trastuzumab-related cardiotoxicity: current data do not provide mechanistic insights or allow for incorporation into clinical practice.
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7
Cardiac issues related to trastuzumab.
Breast. 2004 Jun;13(3):171-2. doi: 10.1016/j.breast.2004.02.008.
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Trastuzumab cardiac side effects: only time will tell.曲妥珠单抗的心脏副作用：只有时间能给出答案。
J Clin Oncol. 2005 Nov 1;23(31):7775-6. doi: 10.1200/JCO.2005.04.1558.
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Irreversible cardiotoxicity after adjuvant treatment with trastuzumab in a case of breast cancer.
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J Natl Cancer Inst. 2009 Apr 1;101(7):448-9. doi: 10.1093/jnci/djp072. Epub 2009 Mar 24.

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In situ quantitative measurement of HER2mRNA predicts benefit from trastuzumab-containing chemotherapy in a cohort of metastatic breast cancer patients.原位定量测量HER2mRNA可预测一组转移性乳腺癌患者接受含曲妥珠单抗化疗的获益情况。
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