Pacary Emilie, Petit Edwige, Bernaudin Myriam
UMR-CNRS 6185, University of Caen, Caen, France.
Neurodegener Dis. 2006;3(1-2):87-93. doi: 10.1159/000092098.
Hypoxia and ischemia in the brain often result in brain dysfunctions and neuronal death during both the neonatal and adult periods. Though the mechanisms contributing to brain injury secondary to hypoxia-ischemia are more clearly defined, there are still no pharmacological treatments available to reduce cell death in the ischemic brain. This review highlights the beneficial effects of hypoxia-inducible factors, such as the transcriptional factor hypoxia-inducible factor-1 and its target genes, as both cytoprotective and regenerative factors, and focuses in particular on one of the most well-known: erythropoietin. Altogether, the data presented in this review suggest that further insights into the role of hypoxia-inducible factors would help develop promising strategies to improve the outcome of hypoxia/ischemia-related brain pathologies.
大脑中的缺氧和缺血在新生儿期和成年期通常都会导致脑功能障碍和神经元死亡。尽管缺氧缺血继发脑损伤的机制已得到更明确的界定，但目前仍没有可用于减少缺血性脑损伤中细胞死亡的药物治疗方法。本综述强调了缺氧诱导因子的有益作用，如转录因子缺氧诱导因子-1及其靶基因，它们作为细胞保护和再生因子，尤其关注其中最著名的一种：促红细胞生成素。总之，本综述中呈现的数据表明，进一步深入了解缺氧诱导因子的作用将有助于制定有前景的策略，以改善缺氧/缺血相关脑疾病的预后。
