Szalai G, LaRue A C, Watson D K
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 165 Ashley Avenue, Charleston, SC 29403, USA.
Cell Mol Life Sci. 2006 Nov;63(21):2460-76. doi: 10.1007/s00018-006-6190-8.
One function of bone marrow megakaryocytes (MKs) is the controlled release of platelets into the circulation. Over the past few years, molecular mechanisms that contribute to MK development and differentiation have begun to be elucidated. This review provides a brief overview of megakaryopoiesis and platelet function, and the importance of selected hematopoietic transcription factors (including GATA-1, FOG, Fli-1, AML1, and NF-E2) and target genes in this biological process. In addition, a discussion of human diseases affecting megakaryopoiesis and mouse models of thrombocytopenia are presented with emphasis on how these systems have and will continue to provide further insights into mechanisms that control the biological functions of the megakaryocytic cell lineage. Ultimately, such knowledge may provide the basis for novel therapeutic approaches for modulation of platelet number and function.
骨髓巨核细胞（MKs）的一项功能是将血小板可控地释放到循环系统中。在过去几年里，有助于MK发育和分化的分子机制已开始得到阐明。本综述简要概述了巨核细胞生成和血小板功能，以及特定造血转录因子（包括GATA-1、FOG、Fli-1、AML1和NF-E2）和靶基因在这一生物学过程中的重要性。此外，还讨论了影响巨核细胞生成的人类疾病和血小板减少症的小鼠模型，重点在于这些系统如何以及将继续为控制巨核细胞谱系生物学功能的机制提供进一步的见解。最终，此类知识可能为调节血小板数量和功能的新型治疗方法提供基础。
