Bradley Patrick J, Rinaldo Alessandra, Suárez Carlos, Shaha Ashok R, Leemans C René, Langendijk Johannes A, Patel Snehal G, Ferlito Alfio
Department of Otorhinolaryngology-Head and Neck Surgery, Queens Medical Centre, Nottingham, UK.
Eur Arch Otorhinolaryngol. 2006 Oct;263(10):879-88. doi: 10.1007/s00405-006-0138-3. Epub 2006 Aug 15.
Squamous cell carcinoma may involve the anterior commissure (AC) area of the laryngeal glottis, and can be grouped morphologically into four groups; (1) tumor confined to the AC, (2) tumor involving one cord and the AC, (3) tumor involving the AC and a portion of both vocal cords, and (4) tumor involving a greater part of one cord and crossing over to involve a variable length of the other cord. Some of these patients when evaluated by imaging, either CT and/or MRI, may demonstrate thyroid cartilage erosion or involvement, thereby upstaging a T1a, T1b into a T3 or a T4 glottic cancer. The majority of patients treated by radiotherapy have only been staged clinically, and hence a failure or recurrence rate of 15%. In patients treated surgically by endoscopic or external surgery, the local recurrence rates are similar at 15%. Therefore, future reporting of patients treated with AC involvement should be staged radiologically, to include CT or MRI, and documentation of the treatment results be reported in subgroups, according to whether there is no cartilage involvement, inner-table cartilage erosion, or through-and-through cartilage invasion. Should endoscopic cordectomy be used, then the type of surgery performed should be based on the classification as suggested by the European Laryngological Society. The use of the above recommendations would allow for more meaningful results to be reported and for cause specific analysis of failure of treatment techniques applied.
鳞状细胞癌可能累及喉声门的前联合(AC)区域,在形态学上可分为四组:(1)肿瘤局限于AC;(2)肿瘤累及一侧声带和AC;(3)肿瘤累及AC及双侧声带的一部分;(4)肿瘤累及一侧声带的大部分并跨越累及另一侧声带的不同长度。这些患者中,部分在接受CT和/或MRI等影像学评估时,可能显示甲状腺软骨侵蚀或受累,从而将T1a、T1b期声门癌升级为T3或T4期。大多数接受放疗的患者仅进行了临床分期,因此失败或复发率为15%。在内镜手术或外部手术治疗的患者中,局部复发率相似,为15%。因此,未来报告累及AC的患者时,应进行包括CT或MRI在内的放射学分期,并根据是否存在软骨未受累、内板软骨侵蚀或贯穿软骨侵犯,在亚组中报告治疗结果。如果使用内镜声带切除术,那么所进行的手术类型应基于欧洲喉科学会建议的分类。采用上述建议将有助于报告更有意义的结果,并对所应用治疗技术的失败原因进行具体分析。