Allescher H D
Zentrum für Innere Medizin, Gastroenterologie, Hepatologie und Stoffwechsel, Klinikum Garmisch-Partenkirchen GmbH, Garmisch-Partenkirchen.
Praxis (Bern 1994). 2006 Aug 2;95(31-32):1169-73. doi: 10.1024/0369-8394.95.31.1169.
Achalasia is a rare motility disorder of the distal esophagus, showing reduced or absent swallow induced relaxation of the lower esophageal sphincter region. The onset of the disease can be very slow and correct diagnosis might be delayed over years. Using exact medical history, upper GI endoscopy and barium swallow X-ray the achalasia can be suspected and can be confirmed by esophageal manometry. Other especially malignant diseases, which can imitate the clinical symptoms, have to be ruled out. Pneumatic balloon dilatation is therapy of first choice in achalasia. Especially in younger patients laparoscopic fundoplication with subsequent antireflux procedure should be offered early in the therapeutic algorithm when dilatation therapy fails. Medical therapy or intrasphincteric injection of botulinum toxin is only an alternative treatment for high risk patients, treatment failures or residual symptoms.
贲门失弛缓症是一种罕见的食管远端动力障碍性疾病,表现为吞咽引起的食管下括约肌区域松弛减弱或消失。该病起病可能非常缓慢,正确诊断可能会延迟数年。通过详细的病史、上消化道内镜检查和吞钡X线检查可怀疑贲门失弛缓症,并可通过食管测压确诊。必须排除其他特别是能够模仿临床症状的恶性疾病。气囊扩张术是贲门失弛缓症的首选治疗方法。特别是对于年轻患者,当扩张治疗失败时,应在治疗方案中尽早提供腹腔镜胃底折叠术及随后的抗反流手术。药物治疗或肉毒杆菌毒素括约肌内注射仅适用于高危患者、治疗失败或有残留症状的替代治疗。