Gold M S, Russo J, Tissot M, Weinhouse G, Riles T
Department of Anesthesiology, New York University Medical Center, NY 10016.
Ann Surg. 1990 Apr;211(4):482-5. doi: 10.1097/00000658-199004000-00016.
The effects of hetastarch and human albumin solutions on perioperative bleeding and coagulation parameters during abdominal aortic aneurysm repair were compared. In two randomized groups of 20 patients, albumin 5% (group 1) or hetastarch 6% (group 2) 1 g/kg was given during surgery. The remaining perioperative fluids consisted of lactated ringers and packed red blood cells. Perioperative coagulation measurements included partial thromboplastin time, prothrombin time, activated clotting time, platelet count, and bleeding time. Estimated blood loss and the total amount of crystalloid and blood infused were also measured. The surgeon, blind to the colloid used, subjectively rated bleeding on a scale of 1 to 10. There was no significant difference between groups for any measured parameter at any time. Measurements of coagulation function were within normal limits for both groups. Hetastarch does not cause clotting disorders in patients undergoing abdominal aortic aneurysm repair, at least if the quantities used in this study are not exceeded.
比较了羟乙基淀粉和人白蛋白溶液对腹主动脉瘤修复术中围手术期出血和凝血参数的影响。在两组各20例患者的随机分组中，手术期间给予5%白蛋白（第1组）或6%羟乙基淀粉（第2组）1 g/kg。其余围手术期液体包括乳酸林格液和浓缩红细胞。围手术期凝血指标包括部分凝血活酶时间、凝血酶原时间、活化凝血时间、血小板计数和出血时间。还测量了估计失血量以及输注的晶体液和血液总量。对所用胶体不知情的外科医生对出血情况进行主观评分，范围为1至10分。在任何时间，两组之间的任何测量参数均无显著差异。两组的凝血功能测量均在正常范围内。羟乙基淀粉不会在接受腹主动脉瘤修复术的患者中引起凝血障碍，至少在本研究中使用的剂量未超限时不会。
