Kirklin J K, Lell W A, Kouchoukos N T
Ann Thorac Surg. 1984 Jan;37(1):40-6. doi: 10.1016/s0003-4975(10)60707-2.
Hydroxyethyl starch or hetastarch (HES), a synthetic colloid for intravascular volume expansion, was compared with albumin after coronary artery operations in 30 patients (15 in each study group). Cardiac index, atrial pressures, heart rate, and systolic blood pressure were similar in both groups. There were no differences in cumulative urine output at 24 hours or in weight change during the first 7 postoperative days. Values for colloid osmotic pressure, as well as for this variable minus left atrial pressure, were lowest soon after bypass but returned to baseline within 4 hours, with no difference between groups in the first 24 hours or 7 days after operation. Coagulation variables were similar, but prothrombin and partial thromboplastin times were higher 12 hours postoperatively and fibrinogen level was lower 7 days postoperatively in the patients receiving HES. There was no clinical evidence of excessive bleeding, although cumulative chest drainage at 12 and 24 hours was slightly higher in the HES group (p = 0.09 and 0.08, respectively). We conclude that hetastarch is a safe and effective colloid to use following coronary operations.
羟乙基淀粉或贺斯（HES）是一种用于血管内容量扩充的合成胶体，在30例冠状动脉手术后的患者中（每个研究组15例），将其与白蛋白进行了比较。两组的心脏指数、心房压力、心率和收缩压相似。术后24小时的累计尿量或术后前7天的体重变化均无差异。胶体渗透压以及该变量减去左心房压力的值在体外循环后不久最低，但在4小时内恢复至基线水平，术后24小时或7天内两组之间无差异。凝血变量相似，但接受HES治疗的患者术后12小时凝血酶原时间和部分凝血活酶时间较高，术后7天纤维蛋白原水平较低。尽管HES组12小时和24小时的累计胸腔引流量略高（分别为p = 0.09和0.08），但没有过度出血的临床证据。我们得出结论，贺斯是冠状动脉手术后使用的一种安全有效的胶体。
