Siniscalchi Antonio, Gallelli Luca, Mercuri Nicola B, Ibbadu Guido Ferreri, De Sarro Giovambattista
Neurology Division, Department of Neuroscience, "Annunziata" Hospital, Cosenza, Italy.
Nutr Neurosci. 2006 Feb-Apr;9(1-2):11-6. doi: 10.1080/10284150600583446.
Many papers documented that Parkinson's disease (PD) patients treated with levodopa (L-dopa) shows elevated plasma homocysteine (Hcy) levels. Several lifestyle factors are able to influence plasma Hcy levels. We review the evidence that L-dopa therapy is related with an increase in plasma Hcy levels and that several behaviours could be able to cause changes in plasma Hcy concentrations. Therefore, there are reasons to suggest that a healthy lifestyle lowering Hcy may prevent this potential iatrogenic complication during L-dopa therapy. Moreover, at present, no controlled prospective studies have evaluated this phenomenon.
许多论文记载，接受左旋多巴（L-多巴）治疗的帕金森病（PD）患者血浆同型半胱氨酸（Hcy）水平升高。多种生活方式因素能够影响血浆Hcy水平。我们综述了L-多巴治疗与血浆Hcy水平升高相关以及多种行为可能导致血浆Hcy浓度变化的证据。因此，有理由认为，采用健康的生活方式降低Hcy水平或许能够预防L-多巴治疗期间这种潜在的医源性并发症。此外，目前尚无对照性前瞻性研究评估过这一现象。
