• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

[关于内源性和外源性γ-羟基丁酸(液体摇头丸)阈值的研究]

[Investigations concerning the threshold value between endogenous and exogenous GHB (liquid ecstasy)].

作者信息

Erdmann Freidoon, Zandt Daniel, Auch Jürgen, Schütz Harald, Weiler Günter, Verhoff Marcel A

机构信息

Institut für Rechtsmedizin der Universität Giessen.

出版信息

Arch Kriminol. 2006 May-Jun;217(5-6):129-36.

PMID:16910296
Abstract

The article describes critical investigations concerning the threshold value between endogenous and exogenous concentrations of gamma-hydroxybutyric acid (GHB/"liquid ecstasy") in human blood. The values of GHB in the blood samples of 50 blood donors and 50 postmortem cases were measured with a validated gas-chromatographic/mass-spectrometric procedure according to the guidelines of the GTFCh (Society of Toxicological and Forensic Chemistry). GHB-concentrations were found to range between 0.11 and 1.56 mg/L (mean value 0.54 mg/L/standard deviation 0.37 mg/L/coefficient of variation 68.4 %) in the donors' blood, and between 2.2 and 116 mg/L (mean value 32.4 mg/L/standard deviation 25.6 mg/L/coefficient of variation 79 %) in the postmortem samples, respectively.

摘要

这篇文章描述了关于人体血液中γ-羟基丁酸(GHB/“液体摇头丸”)内源性和外源性浓度阈值的关键研究。根据毒理和法医化学协会(GTFCh)的指南,采用经过验证的气相色谱/质谱法测量了50名献血者和50例尸检病例血样中的GHB值。发现献血者血液中GHB浓度范围为0.11至1.56毫克/升(平均值0.54毫克/升/标准差0.37毫克/升/变异系数68.4%),尸检样本中GHB浓度范围为2.2至116毫克/升(平均值32.4毫克/升/标准差25.6毫克/升/变异系数79%)。

相似文献

1
[Investigations concerning the threshold value between endogenous and exogenous GHB (liquid ecstasy)].[关于内源性和外源性γ-羟基丁酸(液体摇头丸)阈值的研究]
Arch Kriminol. 2006 May-Jun;217(5-6):129-36.
2
Carbon isotopic ratio analysis by gas chromatography/combustion/isotope ratio mass spectrometry for the detection of gamma-hydroxybutyric acid (GHB) administration to humans.采用气相色谱/燃烧/同位素比率质谱法进行碳同位素比率分析,以检测人体是否摄入γ-羟基丁酸(GHB)。
Rapid Commun Mass Spectrom. 2007;21(24):3956-62. doi: 10.1002/rcm.3298.
3
Gamma-hydroxybutyric acid stability and formation in blood and urine.γ-羟基丁酸在血液和尿液中的稳定性及形成
Forensic Sci Int. 2006 Sep 12;161(2-3):158-62. doi: 10.1016/j.forsciint.2006.01.017. Epub 2006 Jul 18.
4
Site-dependent production of gamma-hydroxybutyric acid in the early postmortem period.死后早期γ-羟基丁酸的部位依赖性产生
Forensic Sci Int. 2005 Mar 10;148(2-3):139-42. doi: 10.1016/j.forsciint.2004.05.002.
5
Endogenous concentrations of GHB in postmortem blood from deaths unrelated to GHB use.与使用γ-羟基丁酸(GHB)无关的死亡案例中,死后血液中GHB的内源性浓度。
J Anal Toxicol. 2014 Oct;38(8):582-8. doi: 10.1093/jat/bku088.
6
Post mortem concentrations of endogenous gamma hydroxybutyric acid (GHB) and in vitro formation in stored blood and urine samples.死后内源性γ-羟基丁酸(GHB)的浓度以及储存血液和尿液样本中的体外生成情况。
Forensic Sci Int. 2014 Oct;243:144-8. doi: 10.1016/j.forsciint.2014.07.019. Epub 2014 Jul 25.
7
Endogenous gamma-hydroxybutyric acid levels in postmortem blood.尸检血液中内源性γ-羟基丁酸水平
Leg Med (Tokyo). 2004 Mar;6(1):47-51. doi: 10.1016/j.legalmed.2003.09.004.
8
GHB in postmortem toxicology. Discrimination between endogenous production from exposure using multiple specimens.死后毒理学中的γ-羟基丁酸。利用多个样本区分内源性产生与接触所致。
Forensic Sci Int. 2004 Jul 16;143(2-3):177-81. doi: 10.1016/j.forsciint.2004.02.036.
9
Source inference of exogenous gamma-hydroxybutyric acid (GHB) administered to humans by means of carbon isotopic ratio analysis: novel perspectives regarding forensic investigation and intelligence issues.通过碳同位素比分析推断人体中外源性γ-羟基丁酸(GHB)的来源:法医学调查和情报问题的新视角。
Anal Bioanal Chem. 2011 May;400(4):1105-12. doi: 10.1007/s00216-011-4891-9. Epub 2011 Apr 1.
10
The possible influence of micro-organisms and putrefaction in the production of GHB in post-mortem biological fluid.微生物和腐败作用对死后生物体液中γ-羟基丁酸(GHB)产生的潜在影响。
Forensic Sci Int. 2004 Jan 28;139(2-3):183-90. doi: 10.1016/j.forsciint.2003.10.018.

引用本文的文献

1
The challenge of post-mortem GHB analysis: storage conditions and specimen types are both important.死后γ-羟基丁酸(GHB)分析面临的挑战:储存条件和样本类型都很重要。
Int J Legal Med. 2020 Jan;134(1):205-215. doi: 10.1007/s00414-019-02150-w. Epub 2019 Oct 9.
2
Endogenous gamma-hydroxybutyric acid (GHB) concentrations in post-mortem specimens and further recommendation for interpretative cut-offs.尸检标本中内源性γ-羟基丁酸(GHB)浓度及解释性临界值的进一步建议。
Int J Legal Med. 2015 Jan;129(1):57-68. doi: 10.1007/s00414-014-1051-8. Epub 2014 Aug 2.
3
Knock-out drugs: their prevalence, modes of action, and means of detection.
敲除药物:其普遍性、作用方式及检测方法
Dtsch Arztebl Int. 2009 May;106(20):341-7. doi: 10.3238/arztebl.2009.0341. Epub 2009 May 15.