Ghildyal Reena, Ho Adeline, Jans David A
Department of Respiratory and Sleep Medicine, Monash Medical Centre, Clayton, Australia.
FEMS Microbiol Rev. 2006 Sep;30(5):692-705. doi: 10.1111/j.1574-6976.2006.00025.x.
Respiratory syncytial virus is the major respiratory pathogen of infants and children worldwide, with no effective treatment or vaccine available. Steady progress has been made in understanding the respiratory syncytial virus life cycle and the consequences of infection, but many areas of respiratory syncytial virus biology remain poorly understood, including the role of subcellular localisation of respiratory syncytial virus gene products such as the matrix protein in the infected host cell. The matrix protein plays a central role in viral assembly and, intriguingly, has been observed to traffic into and out of the nucleus at specific times during the respiratory syncytial virus infectious cycle. Further, the matrix protein has been shown to be able to inhibit transcription, which may be a key to respiratory syncytial virus pathogenesis. This review will focus on the role of the matrix protein in respiratory syncytial virus infection and what is known of its nucleocytoplasmic trafficking, the understanding of which may lead to new therapeutic approaches to combat respiratory syncytial virus, and/or vaccine development.
呼吸道合胞病毒是全球婴幼儿主要的呼吸道病原体，目前尚无有效的治疗方法或疫苗。在了解呼吸道合胞病毒生命周期及感染后果方面已取得稳步进展，但呼吸道合胞病毒生物学的许多领域仍知之甚少，包括呼吸道合胞病毒基因产物（如基质蛋白）在受感染宿主细胞中的亚细胞定位作用。基质蛋白在病毒组装中起核心作用，有趣 的是，在呼吸道合胞病毒感染周期的特定时间，观察到它能进出细胞核。此外，基质蛋白已被证明能够抑制转录，这可能是呼吸道合胞病毒发病机制的关键。本综述将重点关注基质蛋白在呼吸道合胞病毒感染中的作用及其核质运输情况，对其的了解可能会带来对抗呼吸道合胞病毒的新治疗方法和/或疫苗研发。
