Desvaux Mickaël, Hébraud Michel
Institut National de la Recherche Agronomique (INRA), Centre de Recherche Clermont-Ferrand-Theix-Lyon, UR 454 Microbiologie, Equipe Qualité et Sécurité des Aliments (QuaSA), Saint-Genès Champanelle, France.
FEMS Microbiol Rev. 2006 Sep;30(5):774-805. doi: 10.1111/j.1574-6976.2006.00035.x.
Listeria monocytogenes, the etiologic agent of listeriosis, remains a serious public health concern with its frequent occurrence in food coupled with a high mortality rate. The capacity of a bacterium to secrete proteins to or beyond the bacterial cell surface is of crucial importance in the understanding of biofilm formation and bacterial pathogenesis to further develop defensive strategies. Recent findings in protein secretion in Listeria together with the availability of complete genome sequences of several pathogenic L. monocytogenes strains, as well as nonpathogenic Listeria innocua Clip11262, prompted us to summarize the listerial protein secretion systems. Protein secretion would rely essentially on the Sec (Secretion) pathway. The twin-arginine translocation pathway seems encoded in all but one sequenced Listeria. In addition, a functional flagella export apparatus, a fimbrilin-protein exporter, some holins and a WXG100 secretion system are encoded in listerial genomes. This critical review brings new insights into the physiology and virulence of Listeria species.
单核细胞增生李斯特菌是李斯特菌病的病原体，因其频繁出现在食物中且死亡率高，仍然是一个严重的公共卫生问题。细菌向细菌细胞表面或其外分泌蛋白质的能力对于理解生物膜形成和细菌致病性以进一步制定防御策略至关重要。近期关于李斯特菌蛋白质分泌的研究结果，以及几种致病性单核细胞增生李斯特菌菌株和非致病性无害李斯特菌Clip11262完整基因组序列的可得性，促使我们总结李斯特菌的蛋白质分泌系统。蛋白质分泌基本上依赖于Sec（分泌）途径。除了一个已测序的李斯特菌外，双精氨酸转运途径似乎在所有李斯特菌中都有编码。此外，李斯特菌基因组中还编码了一个功能性鞭毛输出装置、一个菌毛蛋白输出器、一些孔蛋白和一个WXG100分泌系统。这篇批判性综述为李斯特菌属的生理学和毒力带来了新的见解。
