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[人体长期禁食时乙醇氧化的抑制作用：果糖输注后的可逆性（作者译）]

[Inhibition of ethanol exidation on prolonged fasting in man: reversibility on fructose infusion(author's transl)].

作者信息

Bode J C, Thiele D

出版信息

Dtsch Med Wochenschr. 1975 Sep 12;100(37):1849-51.

PMID:169115
Abstract

Fasting for over 36 hours was found to inhibit ethanol metabolism in healthy volunteers by 43% (P less than 0.01) compared with values obtained after 12 hours' fasting. Ethanol oxidation was not inhibited by prolonged fasting when it was stimulated by intravenous fructose. The explanation for this effect is thought to lie in the inhibition of alcohol oxidation mainly by limiting the rate of NADH-reoxidation in the liver.

摘要

研究发现，与禁食12小时后测得的值相比，健康志愿者禁食超过36小时会使乙醇代谢受到43%的抑制（P<0.01）。当通过静脉注射果糖刺激乙醇氧化时，长时间禁食并不会抑制其氧化。这种效应的解释被认为主要在于通过限制肝脏中NADH再氧化的速率来抑制酒精氧化。

相似文献

1
[Inhibition of ethanol exidation on prolonged fasting in man: reversibility on fructose infusion(author's transl)].[人体长期禁食时乙醇氧化的抑制作用：果糖输注后的可逆性（作者译）]
Dtsch Med Wochenschr. 1975 Sep 12;100(37):1849-51.
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J Pharmacol Exp Ther. 1979 Oct;211(1):133-9.

引用本文的文献

1
The effects of starving and refeeding on the intra-acinar distribution pattern of alcohol-dehydrogenase activity in rat liver.饥饿和再喂养对大鼠肝脏腺泡内乙醇脱氢酶活性分布模式的影响。
Histochemistry. 1987;86(3):275-9. doi: 10.1007/BF00490258.
2
Alcohol metabolism in man: effect of intravenous fructose infusion on blood ethanol elimination rate following stimulation by phenobarbital treatment or chronic alcohol consumption.人类的酒精代谢：苯巴比妥治疗或长期饮酒刺激后，静脉输注果糖对血液中乙醇消除率的影响。
Klin Wochenschr. 1979 Feb 1;57(3):125-30. doi: 10.1007/BF01476052.
3
The metabolism of alcohol: physiological and pathophysiological aspects.
酒精的代谢：生理与病理生理方面
J R Coll Physicians Lond. 1978 Jan;12(2):122-35.