Chang Jenn-Tzong, Huang Yung-Feng, Lin Yen-Ting, Liu Yung-Ching, Chiu Lin-Hui, Tu Hui-Zin, Hsieh Kai-Sheng
Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2006 Aug;22(8):415-9. doi: 10.1016/S1607-551X(09)70332-8.
Nontuberculous mycobacterium (NTM) is one of the well-known causes of cervicofacial lymphadenopathy in children under 5 years of age. Children often present with a painless cervical mass that fails to respond to conventional antibiotics. They are often referred under the suspicion of a neoplasm or bacterial adenitis rather than NTM cervical lymphadenitis. The lack of systemic symptoms, modest or negative purified protein derivative test and absence of exposure to active tuberculosis are characteristics of NTM lymphadenitis. The diagnosis usually requires the isolation of pathogen or pathologic proof. Complete excision is the choice of treatment by the majority of authors in the literature. This not only enables rapid diagnosis but ensures the lowest recurrence rate. Medical management is sometimes successful when complete resection is impossible or refused. To our knowledge, the incidence of NTM cervical lymphadenitis in children is increasing throughout the world. However, such reports of children in Taiwan is lacking. Clinicians should suspect a possible nontuberculous mycobacterial infection when a cervical lump is found in a child.
非结核分枝杆菌(NTM)是5岁以下儿童颈面部淋巴结病的常见病因之一。儿童常表现为无痛性颈部肿块,对传统抗生素治疗无效。他们常因怀疑肿瘤或细菌性腺炎而非NTM颈淋巴结炎而被转诊。缺乏全身症状、结核菌素试验结果为中度或阴性以及无活动性结核病接触史是NTM淋巴结炎的特征。诊断通常需要分离出病原体或病理证据。文献中大多数作者选择的治疗方法是完整切除。这不仅能实现快速诊断,还能确保最低的复发率。当无法进行或患者拒绝完整切除时,药物治疗有时会取得成功。据我们所知,全球儿童NTM颈淋巴结炎的发病率正在上升。然而,台湾地区缺乏此类儿童病例报告。当儿童发现颈部肿块时,临床医生应怀疑可能是非结核分枝杆菌感染。