急性缺血性卒中后N末端脑钠肽前体的系列测量
Serial measurements of N-terminal pro-brain natriuretic peptide after acute ischemic stroke.
作者信息
Jensen J K, Mickley H, Bak S, Korsholm L, Kristensen S R
机构信息
Department of Cardiology, Odense University Hospital, Odense, Denmark.
出版信息
Cerebrovasc Dis. 2006;22(5-6):439-44. doi: 10.1159/000094997. Epub 2006 Aug 11.
BACKGROUND
The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established.
METHODS
NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke.
RESULTS
NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels > or =615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality.
CONCLUSION
NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality.
背景
N 末端脑钠肽前体（NT-proBNP）的确切时间进程以及在缺血性卒中急性期的预后重要性尚未明确。
方法
对 250 例连续的急性缺血性卒中患者从入院至第 5 天每日测量 NT-proBNP，并在 6 个月随访时再次测量。
结果
NT-proBNP 在症状发作后第 1 天达到峰值（p = 0.007），随后下降直至第 5 天（p = 0.001，方差分析）。在 6 个月随访时，NT-proBNP 水平与第 5 天相比无变化（p = 0.42）。症状发作后第 2 天 NT-proBNP 水平≥615 pg/ml 与 6 个月死亡率相关。
结论
急性缺血性卒中患者 NT-proBNP 在症状发作后第 1 天达到峰值。单次测量 NT-proBNP 似乎是 6 个月死亡率的一个指标。
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