Smalheiser Neil R, Torvik Vetle I
University of Illinois-Chicago, UIC Psychiatric Institute MC912, 1601 W. Taylor Street, Chicago, IL 60612, USA.
Trends Genet. 2006 Oct;22(10):532-6. doi: 10.1016/j.tig.2006.08.007. Epub 2006 Aug 17.
Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typical short-seed complementarity with a specific site within Alu elements that is highly conserved within 3' untranslated regions of human mRNAs. The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets.
最近，我们报道了四种微小RNA与人类mRNA中的MIR/LINE-2元件呈现出完美互补。这一发现引发了一个问题，即微小RNA是否也可能靶向其他基因组重复序列和转座元件。在此，我们证明了近30种人类微小RNA与Alu元件内的一个特定位点表现出典型的短种子互补性，该位点在人类mRNA的3'非翻译区内高度保守。结果表明，人类mRNA中的至少一些Alu元件充当微小RNA的靶标。
