Jordan K, Voigt W, Schmoll H-J
Klinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle/Wittenberg, Ernst-Grube-Strasse 40, 06120 Halle/Salle.
Dtsch Med Wochenschr. 2006 Aug 25;131(34-35):1869-72. doi: 10.1055/s-2006-949172.
Nausea and vomiting are considered as two of the most distressing side effects of chemotherapy. The frequency of nausea and vomiting depends primarily on the emetogenic potential of the chemotherapeutic agents used. With the introduction of the neurokinin-1-receptor-antagonists in combination with 5-HT(3) receptor-antagonists and steroid approximately 70-90 % of patients receiving highly emetogenic chemotherapy can be protected from emesis. Here, the most recent developments in the antiemetic therapy including the latest guidelines for antiemetic prophylaxis are described.
恶心和呕吐被认为是化疗最令人痛苦的两种副作用。恶心和呕吐的发生率主要取决于所用化疗药物的致吐潜力。随着神经激肽-1受体拮抗剂与5-羟色胺（3）受体拮抗剂及类固醇联合使用，接受高致吐性化疗的患者中约70%-90%可预防呕吐。本文描述了止吐治疗的最新进展，包括最新的止吐预防指南。
