Chima Karindeep K, Seldin Edward B, Dodson Thomas B
Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02114, USA.
J Oral Maxillofac Surg. 2006 Sep;64(9):1398-403. doi: 10.1016/j.joms.2006.05.025.
To evaluate outcomes associated with choice of wound management, ie, primary closure or healing by secondary intention, of osseous defects after excision of maxillofacial bone lesions as a guide to clinical practice.
Using a retrospective cohort study design, we enrolled a sample composed of subjects treated for jaw lesions between 1995 and 2003. The primary predictor variable was the wound management choice of the residual jaw defect, classified as primary closure or healing by secondary intention. The primary outcome variable was postoperative inflammatory complications. Other study variables were grouped as demographic, medical/dental history, lesion information, preoperative complications, operative treatment, and follow-up information. Appropriate uni-, bi-, and multivariate statistics were computed.
The sample was composed of 93 subjects with 126 jaw lesions, of which 90 (71.4%) were managed by primary closure. In the bivariate analyses, tobacco use was statistically associated (P < .05) with wound management and near statistically associated (P = .06) with complications. In the multivariate model, after adjusting for the presence of multiple cysts and tobacco use, there was not a statistically significant difference between the 2 wound management choices in terms of postoperative complications.
Our results suggest that the choice of managing the osseous wound, ie, primary closure versus secondary intention, was not associated with increased risk of postoperative inflammatory complications. The implications of these findings are discussed below.
评估颌面部骨病变切除术后骨缺损伤口处理方式(即一期缝合或二期愈合)的相关结局,为临床实践提供指导。
采用回顾性队列研究设计,纳入1995年至2003年间接受颌骨病变治疗的患者样本。主要预测变量是残余颌骨缺损的伤口处理方式,分为一期缝合或二期愈合。主要结局变量是术后炎症并发症。其他研究变量分为人口统计学、医学/牙科病史、病变信息、术前并发症、手术治疗及随访信息。计算了适当的单变量、双变量和多变量统计量。
样本包括93名患者,共126处颌骨病变,其中90处(71.4%)采用一期缝合处理。在双变量分析中,吸烟与伤口处理存在统计学关联(P < .05),与并发症接近统计学关联(P = .06)。在多变量模型中,在调整了多个囊肿的存在和吸烟因素后,两种伤口处理方式在术后并发症方面没有统计学上的显著差异。
我们的结果表明,骨伤口处理方式的选择,即一期缝合与二期愈合,与术后炎症并发症风险增加无关。以下将讨论这些发现的意义。