孕激素与乳腺癌
Progestins and breast cancer.
作者信息
Aupperlee Mark, Kariagina Anastasia, Osuch Janet, Haslam Sandra Z
机构信息
Department of Physiology, Michigan State University. East Lansing, MI 48824, USA.
出版信息
Breast Dis. 2005;24:37-57. doi: 10.3233/bd-2006-24104.
Progesterone (P) regulates proliferation and differentiation in the normal mammary gland in mouse, rat and human. Progesterone has also been implicated in the etiology and pathogenesis of human breast cancer. The focus of this review is on recent advances in understanding the role of the progesterone receptor (PR) and functional significance of PR isoforms, PRA and PRB, in the normal mammary gland and in mammary cancer in mouse, rat and human.
孕酮（P）可调节小鼠、大鼠和人类正常乳腺中的细胞增殖与分化。孕酮也与人类乳腺癌的病因学和发病机制有关。本综述的重点是在理解孕酮受体（PR）的作用以及PR亚型PRA和PRB在小鼠、大鼠和人类正常乳腺及乳腺癌中的功能意义方面的最新进展。
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