Zhang Feng, Xiong Dong-Hai, Wang Wei, Shen Hui, Xiao Peng, Yang Fang, Recker Robert R, Deng Hong-Wen
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, PR China.
Biochem Biophys Res Commun. 2006 Oct 6;348(4):1378-82. doi: 10.1016/j.bbrc.2006.08.008. Epub 2006 Aug 10.
Histidine decarboxylase gene (HDC) encodes histidine decarboxylase which is the crucial enzyme for the biosynthesis of histidine. Studies have shown that histamine is likely to be involved in the regulation of reproduction system. To find the possible correlation between HDC gene and AANM (age at natural menopause), we selected 265 postmenopausal women from 131 nuclear families and performed a transmission disequilibrium test. Significant within-family associations with AANM for SNP rs854163 and SNP rs854158 of HDC gene were observed (P values=0.0018 and 0.0197, respectively). After 1000 permutations, SNP rs854163 still remained significant within-family association with AANM. Consistently, we also detected a significant within-family association between haplotype block 2 (defined by SNP rs854163 and rs860526) and AANM in the haplotype analyses (P value=0.0397). Our results suggest that the HDC gene polymorphisms are significantly associated with AANM in Caucasian women.
组氨酸脱羧酶基因（HDC）编码组氨酸脱羧酶，它是组氨酸生物合成的关键酶。研究表明，组胺可能参与生殖系统的调节。为了寻找HDC基因与自然绝经年龄（AANM）之间可能的相关性，我们从131个核心家庭中选取了265名绝经后女性，并进行了传递不平衡检验。观察到HDC基因的单核苷酸多态性（SNP）rs854163和SNP rs854158与AANM存在显著的家庭内关联（P值分别为0.0018和0.0197）。经过1000次排列后，SNP rs854163与AANM的家庭内关联仍然显著。同样，在单倍型分析中，我们还检测到单倍型块2（由SNP rs854163和rs860526定义）与AANM之间存在显著的家庭内关联（P值=0.0397）。我们的结果表明，HDC基因多态性与白种女性的AANM显著相关。
