Jensen J, Langkilde A R, Frederiksen J L, Sellebjerg F
The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark.
J Neuroimmunol. 2006 Oct;179(1-2):163-72. doi: 10.1016/j.jneuroim.2006.06.024. Epub 2006 Aug 21.
An increased percentage of blood CD8+ T cells from patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) was found to express CD26 and CD69. The percentage of CD26 or CD69 positive CD8+ T cells was higher in patients with MRI evidence of disease dissemination in space or with active MRI lesions than in the remaining patients. Treatment of MS with interferon (IFN)-beta resulted in a decrease in the percentage of CD26 and CD71 positive CD8+ T cells and an increase in the percentage of CD8+ T cells that expressed interleukin (IL)-10 and IL-13. CD8+ T cell activation in MS may be linked to disease activity already at disease onset, and is regulated by treatment with IFN-beta.
研究发现，临床孤立综合征（CIS）提示多发性硬化症（MS）患者血液中表达CD26和CD69的CD8⁺T细胞百分比增加。有空间疾病播散的MRI证据或有活动性MRI病灶的患者中，CD26或CD69阳性CD8⁺T细胞的百分比高于其余患者。用干扰素（IFN）-β治疗MS导致CD26和CD71阳性CD8⁺T细胞百分比降低，而表达白细胞介素（IL）-10和IL-13的CD8⁺T细胞百分比增加。MS中CD8⁺T细胞的激活可能在疾病发作时就与疾病活动相关，并受IFN-β治疗的调节。
