Völkel Pamela, Angrand Pierre-Olivier
Institut de Recherche Interdisciplinaire, CNRS FRE 2963, IRI @ Institut de Biologie de Lille, 1, rue du Pr. Calmette, F-59021 Lille Cedex, France.
Biochimie. 2007 Jan;89(1):1-20. doi: 10.1016/j.biochi.2006.07.009. Epub 2006 Aug 4.
Histone lysine methylation plays a fundamental role in chromatin organization and function. This epigenetic mark is involved in many biological processes such as heterochromatin formation, chromosome X inactivation, genomic imprinting and transcriptional regulation. Here, we review recent advances in how histone lysine methylation participates in these biological events, and the enzymes that control histone lysine methylation and demethylation.
组蛋白赖氨酸甲基化在染色质的组织和功能中起着基础性作用。这种表观遗传标记参与许多生物学过程，如异染色质形成、X染色体失活、基因组印记和转录调控。在此，我们综述了组蛋白赖氨酸甲基化如何参与这些生物学事件的最新进展，以及控制组蛋白赖氨酸甲基化和去甲基化的酶。
