Malovichko Olga L, Petrus Anna S, Krysko Andrei A, Kabanova Tatyana A, Andronati Sergei A, Karaseva Tamara L, Kiriyak Anna V
Department of Medicinal Chemistry, A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine, 86 Lustdorfskaya doroga, 65080 Odessa, Ukraine.
Bioorg Med Chem Lett. 2006 Oct 15;16(20):5294-7. doi: 10.1016/j.bmcl.2006.07.090. Epub 2006 Aug 21.
The novel fibrinogen receptor antagonists containing fragments of 7-amino-1,2,3,4-tetrahydroisoquinoline and isophthalic acids were synthesized and successfully tested for their ability to inhibit platelet aggregation in vitro and to block FITC-Fg binding to alpha(IIb)beta(3) on washed human platelets.
合成了含有7-氨基-1,2,3,4-四氢异喹啉片段和间苯二甲酸的新型纤维蛋白原受体拮抗剂，并成功测试了它们在体外抑制血小板聚集以及阻断FITC-纤维蛋白原与洗涤过的人血小板上α(IIb)β(3)结合的能力。
