哌仑西平对胆囊收缩素刺激的犬胰腺外分泌的影响。

Effects of pirenzepine on CCK-stimulated canine pancreatic exocrine secretion.

Salido G M, Gil M Z, Pariente J A, Pozo M J, Madrid J A

Department of Physiology, Faculty of Veterinary Science, University of Extremadura, Caceres, Spain.

Gen Pharmacol. 1990;21(2):195-8. doi: 10.1016/0306-3623(90)90900-7.

Abstract

The effects of the anticholinergic compound pirenzepine on pancreatic secretion stimulated by intravenous infusions of increasing doses of CCK (0.025-0.4 Ivy Dog Unit/kg/min) were investigated in fasting anaesthetized dogs. 2. Pirenzepine (0.75 mg/kg i.v.) slightly reduced the increases in the pancreatic juice secretion evoked by CCK. 3. Similar results were obtained with others anticholinergic compounds as atropine (3 mg/kg i.v.) and hexametonium (5 mg/kg i.v.).

摘要

在禁食的麻醉犬中，研究了抗胆碱能化合物哌仑西平对静脉输注递增剂量的胆囊收缩素（CCK，0.025 - 0.4 Ivy犬单位/千克/分钟）刺激胰腺分泌的影响。2. 哌仑西平（静脉注射0.75毫克/千克）略微降低了CCK引起的胰液分泌增加。3. 其他抗胆碱能化合物如阿托品（静脉注射3毫克/千克）和六甲铵（静脉注射5毫克/千克）也得到了类似结果。