Lucas Katherine E, Armenian Haroutune K, Petersen Gloria M, Rowe Peter C
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E6148, Baltimore, MD 21205, USA.
Europace. 2006 Oct;8(10):846-51. doi: 10.1093/europace/eul092. Epub 2006 Aug 18.
We hypothesized that family history of fainting is a risk factor for adult-onset neurally mediated hypotension (NMH) in patients who present with chronic fatigue rather than fainting.
A nested case-control study of Gulf War veterans gathered fainting histories directly from 197 first-degree relatives of 16 fatigued NMH cases, 26 fatigued controls, and 17 healthy controls. NMH status was determined by tilt testing. Female relatives of fatigued controls reported more fainting than female relatives of cases (P<0.01); there were no significant differences in the frequency of fainting in male relatives by case or control status, or in either gender by age at first faint or by familial relationship to the proband. The odds of NMH patients giving any family history of fainting were 0.56 (95% CI 0.15, 2.07). Recurrence risks calculated using lifetime prevalences of fainting in male military personnel of similar age to our participants were low (1.5-1.7) and did not differ by case or control status.
Family history of fainting is not a risk factor for adult-onset NMH in fatigued veterans. Our findings may differ from other studies of familial aggregation in NMH because of study methods or because NMH-fatiguers may differ from NMH-fainters.
我们假设，对于表现为慢性疲劳而非晕厥的患者，晕厥家族史是成人起病的神经介导性低血压（NMH）的一个危险因素。
一项针对海湾战争退伍军人的巢式病例对照研究，直接收集了16例疲劳性NMH病例、26例疲劳对照和17例健康对照的197名一级亲属的晕厥病史。通过直立倾斜试验确定NMH状态。疲劳对照的女性亲属报告的晕厥情况比病例的女性亲属更多（P<0.01）；病例组或对照组男性亲属的晕厥频率，以及按首次晕厥年龄或与先证者的家族关系划分的任一性别的晕厥频率，均无显著差异。NMH患者有任何晕厥家族史的几率为0.56（95%可信区间0.15，2.07）。使用与我们的参与者年龄相似的男性军事人员的晕厥终生患病率计算的复发风险较低（1.5 - 1.7），且不因病例或对照状态而异。
晕厥家族史不是疲劳退伍军人成人起病NMH的危险因素。由于研究方法或NMH - 疲劳者可能与NMH - 晕厥者不同，我们的研究结果可能与其他关于NMH家族聚集性的研究不同。
