Gliner B E, Murakawa Y, Thakor N V
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Pacing Clin Electrophysiol. 1990 Apr;13(4):425-31. doi: 10.1111/j.1540-8159.1990.tb02057.x.
Seventy or so defibrillation trials were typically attempted to determine the relationship between defibrillation success rate and energy (DSRE). Clinically, it may be desirable to estimate the DSRE relationship with fewer trials. We used the statistical resampling technique called the "bootstrap" to determine the number of defibrillation trials necessary for an accurate estimation of the DSRE relationship. The bootstrap technique assumes that the observed database is the maximum likelihood sample of the estimated population. The observed database is repeatedly resampled to produce a large bootstrap data-base and the bootstrap best estimate of a statistic is determined. DSRE data were obtained from ten dogs (20.5 +/- 1.5 kg). We bootstrapped our experimental DSRE data by two methods: (1) randomly choosing with replacement a specified number of defibrillation trials per energy; and (2) randomly choosing with replacement a specified number of defibrillation trials per bootstrap replication. For both bootstrap techniques, 100 replications were made. We performed a linear regression analysis on the bootstrap success rates and the observed success rates determined from 71.0 +/- 6.8 defibrillation attempts from each of the ten dogs. We concluded that 28 defibrillation trials are necessary to estimate the observed DSRE relationship with a correlation coefficient of 0.95.
通常会尝试进行约70次除颤试验，以确定除颤成功率与能量之间的关系（DSRE）。临床上，可能希望通过较少的试验来估计DSRE关系。我们使用称为“自助法”的统计重采样技术来确定准确估计DSRE关系所需的除颤试验次数。自助法假定观察到的数据库是估计总体的最大似然样本。对观察到的数据库进行重复重采样，以生成一个大型自助数据库，并确定统计量的自助最佳估计值。DSRE数据取自10只狗（20.5±1.5千克）。我们通过两种方法对实验性DSRE数据进行自助抽样：（1）对每个能量随机有放回地选择指定数量的除颤试验；（2）对每次自助重复随机有放回地选择指定数量的除颤试验。对于这两种自助技术，均进行了100次重复。我们对自助成功率以及从10只狗中的每只狗进行的71.0±6.8次除颤尝试所确定的观察到的成功率进行了线性回归分析。我们得出结论，要以0.95的相关系数估计观察到的DSRE关系，需要进行28次除颤试验。
