Church J, Goyal S, Tyagi A K, Scott R A H, Stavrou P
Birmingham and Midland Eye Centre, Sandwell and West Birmingham NHS Trusts, Birmingham, UK.
Eye (Lond). 2007 Sep;21(9):1230-3. doi: 10.1038/sj.eye.6702550. Epub 2006 Aug 18.
To describe a rare association of cytomegalovirus (CMV) retinitis.
Report of three patients with chronic lymphocytic leukaemia (CLL) who developed CMV retinitis.
The diagnosis was established by the detection of CMV DNA by polymerase chain reaction analysis of aqueous and/or vitreous humour. CD4+ T-lymphocyte count was reduced in two patients and normal in the third one. There was bilateral involvement in two of the three patients. There was delay of 8-10 months in diagnosis. The visual outcome was poor in four out of the five eyes involved owing to optic atrophy or total retinal detachment with proliferative vitreoretinopathy.
Increased awareness of CMV retinitis in patients who have received immunosuppression for haematological malignancies, such as CLL, could lead to earlier diagnosis and possibly better visual outcome.
描述巨细胞病毒（CMV）视网膜炎的一种罕见关联。
报告3例慢性淋巴细胞白血病（CLL）患者发生CMV视网膜炎的情况。
通过对房水和/或玻璃体液进行聚合酶链反应分析检测CMV DNA来确诊。2例患者CD4 + T淋巴细胞计数降低，第3例正常。3例患者中有2例为双侧受累。诊断延迟8 - 10个月。受累的5只眼中有4只视力预后较差，原因是视神经萎缩或伴有增殖性玻璃体视网膜病变的完全视网膜脱离。
提高对接受血液系统恶性肿瘤（如CLL）免疫抑制治疗患者中CMV视网膜炎的认识，可能会导致更早诊断并可能获得更好的视力预后。
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