大鼠单侧额叶局灶性脑静脉闭塞模型。
A model of unilateral frontal focal cerebral venous occlusion in the rat.
作者信息
Aydin K, Cokluk C, Kaplan S, Rakunt C, Celik F
机构信息
Department of Neurosurgery, Medical Faculty, Ondokuzmayis University, Samsun, Turkey.
出版信息
Minim Invasive Neurosurg. 2006 Jun;49(3):143-6. doi: 10.1055/s-2006-944246.
OBJECTIVE
The aim of this experimental study was to create a new focal venous infarction model in rats.
METHOD
20-male Sprague-Dawley rats were used in this experiment. Unilateral frontal strip craniectomy was done in front of the coronal suture. Frontal veins were observed by using the operative microscope. In this study we used the bipolar coagulation method over the transparent dura mater for occlusion of the bridging veins for venous infarction. Specimens were evaluated by histopathological techniques.
RESULTS
Unilateral frontal hemispheric swelling, midline shift, brain edema, subcortical petechial hemorrhage, hemorrhagic infarction and necrosis were the histopathological findings on microscopic examination.
CONCLUSION
Our results revealed that the bipolar coagulation method over the transparent dura mater for occlusion of the unilateral frontal cortical veins for venous infarction might be a new experimental model in the evaluation of brain damage after disturbance to the venous circulation.
目的
本实验研究的目的是在大鼠中创建一种新的局灶性静脉梗死模型。
方法
本实验使用20只雄性Sprague-Dawley大鼠。在冠状缝前方进行单侧额部开颅术。使用手术显微镜观察额静脉。在本研究中，我们在透明硬脑膜上采用双极电凝法闭塞桥静脉以造成静脉梗死。通过组织病理学技术对标本进行评估。
结果
显微镜检查的组织病理学发现为单侧额叶半球肿胀、中线移位、脑水肿、皮质下瘀点出血、出血性梗死和坏死。
结论
我们的结果表明，在透明硬脑膜上采用双极电凝法闭塞单侧额叶皮质静脉以造成静脉梗死，可能是评估静脉循环紊乱后脑损伤的一种新的实验模型。
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