Cokluk C, Aydin K, Korkmaz A, Senel A, Iyigün O, Onder A
Department of Neurosurgery, Medical Faculty, Ondokuzmayis University, Samsun, Turkey.
Minim Invasive Neurosurg. 2005 Jun;48(3):149-53. doi: 10.1055/s-2004-830264.
A new rat model of the sacrifice of the anterior and posterior cortical anastomotic veins by the microsurgical technique was used to evaluate venous infarction. 20 male Sprague-Dawley rats were used in this experiment. Small burr-holes were done over the anterior and posterior anastomotic veins. After the precise description of these vessels, bipolar coagulation and micro-scissor was used for sacrifice. Specimens were evaluated by histopathological techniques. Hemispheric swelling, midline shift, brain edema, subcortical petechial hemorrhage, infarction and necrosis were histopathological findings on the microscopic examination. Our results revealed that the sacrifice of the anterior and posterior anastomotic veins was a very successful model in the evaluation of brain damage after the disturbance to the venous circulation.
采用一种新的通过显微外科技术牺牲大脑前、后皮质吻合静脉的大鼠模型来评估静脉梗死。本实验使用了20只雄性Sprague-Dawley大鼠。在前、后吻合静脉上方钻小骨孔。在精确描述这些血管后，使用双极电凝和显微剪进行血管牺牲。通过组织病理学技术对标本进行评估。半球肿胀、中线移位、脑水肿、皮质下瘀点出血、梗死和坏死是显微镜检查的组织病理学发现。我们的结果表明，牺牲大脑前、后吻合静脉是评估静脉循环紊乱后脑损伤的一个非常成功的模型。
