单侧内侧颞叶癫痫双侧损伤的体积证据。
Volumetric evidence of bilateral damage in unilateral mesial temporal lobe epilepsy.
作者信息
Araújo David, Santos Antônio C, Velasco Tonicarlo R, Wichert-Ana Lauro, Terra-Bustamante Vera C, Alexandre Veriano, Carlotti Carlos G, Assirati João A, Machado Hélio Rubens, Walz Roger, Leite João P, Sakamoto Américo C
机构信息
Department of Neurology, Ribeirão Preto School of Medicine, University of São Paulo, Brazil.
出版信息
Epilepsia. 2006 Aug;47(8):1354-9. doi: 10.1111/j.1528-1167.2006.00605.x.
PURPOSE
We sought to analyze the contralateral volumes of the temporal pole, posterior segment of the temporal lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with temporal lobe epilepsy (TLE) due to histologically proven mesial temporal lobe sclerosis (MTLS), seizure free for >or=4 years of postsurgical follow-up.
METHODS
Forty-six (23 male) TLE patients, operated on between 1996 and 2001, with histopathologic diagnosis of MTLS, and a postsurgical follow-up of >or=4 years, had their temporal lobe structures manually segmented, measured, and compared with those of 23 normal volunteers, paired as groups for sex, age, and handedness.
RESULTS
The mean volumes of the contralateral temporal pole, hippocampus, and parahippocampal gyrus in TLE patients were significantly lower than those in controls.
CONCLUSIONS
MRI volumetric data show that the damage in TLE due to MTS may be more widespread and bilateral, even in patients with unilateral TLE by clinical and neurophysiological criteria. Our results are relevant to the discussion of epileptogenic mechanisms in TLE.
目的
我们试图分析经组织学证实为内侧颞叶硬化（MTLS）且术后随访4年以上无癫痫发作的颞叶癫痫（TLE）患者对侧颞极、颞叶后段、杏仁核、海马及海马旁回的体积。
方法
46例（23例男性）于1996年至2001年间接受手术的TLE患者，经组织病理学诊断为MTLS，术后随访4年以上，对其颞叶结构进行手动分割、测量，并与23名正常志愿者的颞叶结构进行比较，按性别、年龄和利手进行配对分组。
结果
TLE患者对侧颞极、海马及海马旁回的平均体积显著低于对照组。
结论
MRI体积数据显示，即使是根据临床和神经生理学标准诊断为单侧TLE的患者，MTS所致的TLE损伤可能更广泛且为双侧性。我们的结果与TLE癫痫发生机制的讨论相关。
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