Song Chengru, Zhang Xiaonan, Han Shaoqiang, Ma Keran, Wang Kefan, Mao Xinyue, Lian Yajun, Zhang Xianchang, Zhu Jinxia, Zhang Yong, Cheng Jingliang
Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China.
Front Hum Neurosci. 2022 Aug 31;16:971062. doi: 10.3389/fnhum.2022.971062. eCollection 2022.
Temporal lobe epilepsy (TLE) is the most prevalent refractory focal epilepsy and is more likely accompanied by cognitive impairment. The fully understanding of the neuronal activity underlying TLE is of great significance.
This study aimed to comprehensively explore the potential brain activity abnormalities affected by TLE and detect whether the changes were associated with cognition.
Six static intrinsic brain activity (IBA) indicators [amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo), degree centrality (DC), global signal correlation (GSCorr), and voxel-mirrored homotopic connectivity (VMHC)] and their corresponding dynamic indicators, such as dynamic ALFF (dALFF), dynamic fALFF (dfALFF), dynamic ReHo (dReHo), dynamic DC (dDC), dynamic VMHC (dVMHC), and dynamic GSCorr (dGSCorr), in 57 patients with unilateral TLE and 42 healthy volunteers were compared. Correlation analyses were also performed between these indicators in areas displaying group differences and cognitive function, epilepsy duration, and severity.
Marked overlap was present among the abnormal brain regions detected using various static and dynamic indicators, primarily including increased ALFF/dALFF/fALFF in the bilateral medial temporal lobe and thalamus, decreased ALFF/dALFF/fALFF in the frontal lobe contralateral to the epileptogenic side, decreased fALFF, ReHo, dReHo, DC, dDC, GSCorr, dGSCorr, and VMHC in the temporal neocortex ipsilateral to the epileptogenic foci, decreased dReHo, dDC, dGSCorr, and dVMHC in the occipital lobe, and increased ALFF, fALFF, dfALFF, ReHo, and DC in the supplementary motor area ipsilateral to the epileptogenic foci. Furthermore, most IBA indicators in the abnormal brain region significantly correlated with the duration of epilepsy and several cognitive scale scores ( < 0.05).
The combined application of static and dynamic IBA indicators could comprehensively reveal more real abnormal neuronal activity and the impairment and compensatory mechanisms of cognitive function in TLE. Moreover, it might help in the lateralization of epileptogenic foci and exploration of the transmission and inhibition pathways of epileptic activity.
颞叶癫痫（TLE）是最常见的难治性局灶性癫痫，更易伴有认知障碍。全面了解TLE潜在的神经元活动具有重要意义。
本研究旨在全面探索受TLE影响的潜在脑活动异常，并检测这些变化是否与认知相关。
比较了57例单侧TLE患者和42名健康志愿者的6种静态脑内固有活动（IBA）指标[低频振幅（ALFF）、分数ALFF（fALFF）、局部一致性（ReHo）、度中心性（DC）、全局信号相关性（GSCorr）和体素镜像同伦连接性（VMHC）]及其相应的动态指标，如动态ALFF（dALFF）、动态fALFF（dfALFF）、动态ReHo（dReHo）、动态DC（dDC）、动态VMHC（dVMHC）和动态GSCorr（dGSCorr）。还对显示组间差异的区域中的这些指标与认知功能、癫痫持续时间和严重程度进行了相关性分析。
使用各种静态和动态指标检测到的异常脑区之间存在明显重叠，主要包括双侧内侧颞叶和丘脑的ALFF/dALFF/fALFF增加，致痫侧对侧额叶的ALFF/dALFF/fALFF降低，致痫灶同侧颞叶新皮质的fALFF、ReHo、dReHo、DC、dDC、GSCorr、dGSCorr和VMHC降低，枕叶的dReHo、dDC、dGSCorr和dVMHC降低，以及致痫灶同侧辅助运动区的ALFF、fALFF、dfALFF、ReHo和DC增加。此外，异常脑区中的大多数IBA指标与癫痫持续时间和几个认知量表评分显著相关（<0.05）。
静态和动态IBA指标的联合应用可以全面揭示TLE中更真实的异常神经元活动以及认知功能的损害和代偿机制。此外，它可能有助于致痫灶的定位以及癫痫活动的传播和抑制途径的探索。
