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CD5（Ly-1）阴性的传统脾脏B细胞对CBA和BW小鼠中的菠萝蛋白酶蚀斑形成细胞反应有显著贡献。

CD5 (Ly-1)-negative, conventional splenic B cells make a substantial contribution to the bromelain plaque-forming cell response in CBA and BW mice.

作者信息

Andrew E M, Annis W, Kahan M, Maini R N

机构信息

Division of Clinical Immunology, Kennedy Institute of Rheumatology, London, U.K.

出版信息

Immunology. 1990 Apr;69(4):515-8.

PMID:1692301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385621/
Abstract

CD5 (Ly-1) B cells are a minor subpopulation in mouse spleen and are thought to be responsible for the production of natural autoantibodies to bromelain-treated autologous erythrocytes (Br-RBC). Here it is shown that substantial numbers of conventional, CD5-negative, splenic B cells also secrete these antibodies in CBA and (NZB x NZW)F1 mice, whereas in NZB and BALB/c mice they are all produced by the CD5 B-cell population. However, stimulation with bacterial lipopolysaccharide in vivo preferentially activates the CD5 B-cell group to anti-Br-RBC antibody secretion.

摘要

CD5（Ly-1）B细胞是小鼠脾脏中的一个次要亚群，被认为负责产生针对菠萝蛋白酶处理的自体红细胞（Br-RBC）的天然自身抗体。本文表明，在CBA和（NZB×NZW）F1小鼠中，大量传统的、CD5阴性的脾脏B细胞也分泌这些抗体，而在NZB和BALB/c小鼠中，它们均由CD5 B细胞群体产生。然而，体内用细菌脂多糖刺激可优先激活CD5 B细胞群体分泌抗Br-RBC抗体。

相似文献

1
CD5 (Ly-1)-negative, conventional splenic B cells make a substantial contribution to the bromelain plaque-forming cell response in CBA and BW mice.CD5（Ly-1）阴性的传统脾脏B细胞对CBA和BW小鼠中的菠萝蛋白酶蚀斑形成细胞反应有显著贡献。
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本文引用的文献

1
Regulation of growth and proliferation in B cell subpopulations.B细胞亚群中生长与增殖的调控
Immunol Rev. 1982;64:161-82. doi: 10.1111/j.1600-065x.1982.tb00423.x.
2
Ly-1 B cells: functionally distinct lymphocytes that secrete IgM autoantibodies.Ly-1 B细胞：分泌IgM自身抗体的功能独特的淋巴细胞。
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2494-8. doi: 10.1073/pnas.81.8.2494.
3
The "Ly-1 B" cell subpopulation in normal immunodefective, and autoimmune mice.正常、免疫缺陷及自身免疫小鼠中的“Ly-1 B”细胞亚群。
J Exp Med. 1983 Jan 1;157(1):202-18. doi: 10.1084/jem.157.1.202.
4
A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells.一种用于计数特异性抗体分泌细胞的固相免疫酶技术。
J Immunol Methods. 1983 Feb 25;57(1-3):301-9. doi: 10.1016/0022-1759(83)90091-1.
5
Idiotypic specificity of surface immunoglobulin and the maturation of leukemic bone-marrow-derived lymphocytes.表面免疫球蛋白的独特型特异性与白血病骨髓来源淋巴细胞的成熟
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4487-90. doi: 10.1073/pnas.71.11.4487.
6
Large numbers of cells in normal mice produce antibody components of isologous erythrocytes.正常小鼠中的大量细胞产生同种红细胞的抗体成分。
Nature. 1974 Dec 20;252(5485):749-51. doi: 10.1038/252749a0.
7
Autoantibodies against mouse bromelain-modified RBC are specifically inhibited by a common membrane phospholipid, phosphatidylcholine.针对小鼠菠萝蛋白酶修饰红细胞的自身抗体被一种常见的膜磷脂——磷脂酰胆碱特异性抑制。
Immunology. 1985 Jun;55(2):263-9.
8
Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment.种系抗体V区作为B细胞区室中克隆持久性和恶性生长的决定因素。
EMBO J. 1988 Dec 1;7(12):3693-703. doi: 10.1002/j.1460-2075.1988.tb03251.x.
9
Genetic influence on the levels of circulating CD5 B lymphocytes.基因对循环CD5 B淋巴细胞水平的影响。
J Immunol. 1987 Aug 15;139(4):1060-4.
10
The Ly-1 B cell lineage.Ly-1 B细胞谱系。
Immunol Rev. 1986 Oct;93:81-102. doi: 10.1111/j.1600-065x.1986.tb01503.x.

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