Dang Xi-Qiang, Yi Zhu-Wen, He Xiao-Jie, Mo Shuang-Hong, Xu Zi-Chuan
Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2006 Aug;8(4):275-8.
To investigate the pathological changes of liver in children with hepatitis B virus associated glomerulonephritis (HBV-GN).
Thirteen children with HBV-GN (aged from 2-14 years) underwent renal and liver biopsy. The biopsy findings were analyzed.
Different degrees of hepatic lesions were seen in all of the 13 patients, mild lesions accounting for 69.2% (9/13). HBSAg positive was the most common in the liver tissue [76.9% (10/13)]. Among the renal lesions, membranous glomerulopathy accounted for 69.2%( 9/13), followed by membranoproliferative glomerulonephritis 30.8% (4/13). HBsAg and HBcAg positive were presented in all patients' kidney tissues. HBV antigens were detected in stroma between nephric tubule in all samples. Four patients presented with HBcAg positive in both live and kidneys.
The children with HBV-GN couple with liver lesions. The severity of the renal lesions is not always accord with that of the liver lesions. The appearance of HBcAg in both kidneys and liver indicates severe lesions of the two organs. It is suggested that a liver-kidney holistic treatment is necessary for children with HBV-GN.
探讨乙型肝炎病毒相关性肾小球肾炎（HBV-GN）患儿肝脏的病理变化。
对13例HBV-GN患儿（年龄2 - 14岁）进行肾活检和肝活检，并对活检结果进行分析。
13例患儿均有不同程度的肝脏病变，轻度病变占69.2%（9/13）。肝组织中最常见的是HBsAg阳性[76.9%（10/13）]。在肾脏病变中，膜性肾小球病占69.2%（9/13），其次是膜增生性肾小球肾炎30.8%（4/13）。所有患儿肾组织中均出现HBsAg和HBcAg阳性。所有样本的肾小管间质中均检测到HBV抗原。4例患儿肝脏和肾脏中均出现HBcAg阳性。
HBV-GN患儿伴有肝脏病变。肾脏病变的严重程度并不总是与肝脏病变一致。肾脏和肝脏中均出现HBcAg表明两个器官均有严重病变。建议对HBV-GN患儿进行肝肾整体治疗。
