Ko Heung-Kyu, Shin Ji Hoon, Song Ho-Young, Kim Yong Jae, Ko Gi-Young, Yoon Hyun-Ki, Sung Kyu-Bo
Department of Radiology, Seoul Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-2dong, Songpa-gu, Seoul 138-736, Korea.
J Vasc Interv Radiol. 2006 Aug;17(8):1327-33. doi: 10.1097/01.RVI.0000232686.29864.0A.
To evaluate the clinical effectiveness and long-term results of balloon dilation treatment for strictures secondary to surgical repair of esophageal atresia (EA) in 29 children.
The study involved 29 children aged 1-60 months with strictures of greater than 50% at anastomotic sites. The interval between surgical repair and balloon dilation ranged from 1 to 36 months (mean, 6.4 months). All procedures were performed under general anesthesia with use of fluoroscopic guidance. Balloon catheter diameters ranged from 8 mm to 16 mm. Outcome parameters measured included the number of dilations, procedural success rates, primary and secondary clinical success rates, and complications such as esophageal perforation. Primary clinical success was defined as an absence of dysphagia for at least 1 year and weight gain appropriate to the patient's age after initial balloon dilation. Secondary clinical success was defined as an absence of dysphagia for at least 1 year after the final dilation and weight gain appropriate to the patient's age after one or more balloon dilation sessions.
A total of 44 balloon dilation sessions were performed, with patients undergoing one to five dilation procedures (mean, 1.6 per patient; median, 1 per patient). Primary and secondary clinical success rates were 59% (17 of 29) and 93% (27 of 29), respectively. During the mean follow-up period of 3.1 years (range, 1-12 y), all 27 children with clinical success showed no recurring symptoms. In terms of complications, transmural perforation occurred in three children (10%), two of whom received conservative management and one of whom underwent surgery for combined esophageal rupture and esophagotracheal fistula. No mortalities occurred.
Balloon dilation is a safe and effective procedure with excellent long-term results for the treatment of anastomotic strictures secondary to surgical repair of EA in a pediatric population.
评估29例儿童食管闭锁(EA)手术修复后继发狭窄的球囊扩张治疗的临床疗效和长期结果。
本研究纳入29例年龄在1至60个月之间、吻合口狭窄超过50%的儿童。手术修复与球囊扩张的间隔时间为1至36个月(平均6.4个月)。所有操作均在全身麻醉和透视引导下进行。球囊导管直径为8毫米至16毫米。测量的结果参数包括扩张次数、操作成功率、初次和二次临床成功率以及诸如食管穿孔等并发症。初次临床成功定义为初次球囊扩张后至少1年无吞咽困难且体重增加符合患者年龄。二次临床成功定义为末次扩张后至少1年无吞咽困难且经过一次或多次球囊扩张疗程后体重增加符合患者年龄。
共进行了44次球囊扩张疗程,患者接受了1至5次扩张操作(平均每位患者1.6次;中位数每位患者1次)。初次和二次临床成功率分别为59%(29例中的17例)和93%(29例中的27例)。在平均3.1年(范围1至12年)的随访期内,所有27例临床成功的儿童均未出现复发症状。在并发症方面,3例儿童(10%)发生了透壁穿孔,其中2例接受了保守治疗,1例因合并食管破裂和食管气管瘘接受了手术治疗。无死亡病例发生。
对于儿科患者中EA手术修复后继发的吻合口狭窄,球囊扩张是一种安全有效的治疗方法,长期效果良好。