Müller-Vahl K R
Abteilung für Klinische Psychiatrie und Psychotherapie, Medizinische Hochschule Hannover, Carl-Neuberg-Stasse 1, 30625 Hannover.
Nervenarzt. 2007 Mar;78(3):264, 266-8, 270-1. doi: 10.1007/s00115-006-2131-x.
The treatment of Tourette's syndrome is a challenge. Dopamine receptor antagonists are the drugs of first choice for the treatment of tics. Because large controlled trials are lacking, there is no consensus about which of the different neuroleptic drugs should be preferred. In Germany, tiapride seems to be used most often for the treatment of tics in children - although only one small controlled trial has been performed on it till now. In adults, other dopamine receptor antagonists such as risperidone, pimozide, and sulpiride seem to be more effective than tiapride. Today it is unknown whether new atypical neuroleptic drugs including the benzamide amisulpride are more effective than the older benzamides tiapride and sulpiride.
抽动秽语综合征的治疗是一项挑战。多巴胺受体拮抗剂是治疗抽动的首选药物。由于缺乏大型对照试验，对于应优先选用哪种不同的抗精神病药物尚无共识。在德国，硫必利似乎是治疗儿童抽动最常用的药物——尽管迄今为止仅对其进行过一项小型对照试验。在成人中，其他多巴胺受体拮抗剂如利培酮、匹莫齐特和舒必利似乎比硫必利更有效。目前尚不清楚包括苯甲酰胺类阿立哌唑在内的新型非典型抗精神病药物是否比旧的苯甲酰胺类药物硫必利和舒必利更有效。
