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Radiation sensitization by an iodine-labelled DNA ligand.

作者信息

Martin R F, Murray V, D'Cunha G, Pardee M, Kampouris E, Haigh A, Kelly D P, Hodgson G S

机构信息

Molecular Sciences Group, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia.

出版信息

Int J Radiat Biol. 1990 May;57(5):939-46. doi: 10.1080/09553009014551061.

DOI:10.1080/09553009014551061
PMID:1692580
Abstract

An iodinated DNA ligand, iodo Hoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.

摘要

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