解读传感器：致密斑之谜
Making sense of the sensor: mysteries of the macula densa.
作者信息
Blantz R C
机构信息
University of California-San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA.
出版信息
Kidney Int. 2006 Sep;70(5):828-30. doi: 10.1038/sj.ki.5001739.
PMID:16929331
Abstract
Increases in luminal NaCl concentration at the macula densa (MD), the sensing element, activate tubuloglomerular feedback (TGF). MD cell volume increases when increments are isosmotic and shrinks if osmolality increases. This interesting finding introduces additional complexity to the role of the MD in TGF.
摘要
致密斑（MD）作为传感元件，其管腔内氯化钠浓度的升高会激活球管反馈（TGF）。当增量为等渗时，MD细胞体积增加；而当渗透压升高时，细胞体积则会缩小。这一有趣的发现为MD在TGF中的作用增添了额外的复杂性。
相似文献
1
Making sense of the sensor: mysteries of the macula densa.解读传感器：致密斑之谜
Kidney Int. 2006 Sep;70(5):828-30. doi: 10.1038/sj.ki.5001739.
2
Unraveling the relationship between macula densa cell volume and luminal solute concentration/osmolality.揭示致密斑细胞体积与管腔溶质浓度/渗透压之间的关系。
Kidney Int. 2006 Sep;70(5):865-71. doi: 10.1038/sj.ki.5001633. Epub 2006 Jul 5.
3
Inhibition of apical Na+/H+ exchangers on the macula densa cells augments tubuloglomerular feedback.抑制致密斑细胞顶端的钠/氢交换体可增强球管反馈。
Hypertension. 2003 Mar;41(3 Pt 2):688-91. doi: 10.1161/01.HYP.0000048863.75711.B2. Epub 2002 Dec 30.
4
Resetting of tubuloglomerular feedback by interrupting early distal flow.通过中断早期远端血流来重置肾小管-肾小球反馈。
Acta Physiol Scand. 1993 May;148(1):63-8. doi: 10.1111/j.1748-1716.1993.tb09532.x.
5
Nystatin and valinomycin induce tubuloglomerular feedback.制霉菌素和缬氨霉素可诱导球管反馈。
Am J Physiol Renal Physiol. 2001 Dec;281(6):F1102-8. doi: 10.1152/ajprenal.00357.2000.
6
Macula densa feedback control of glomerular filtration: role of cytosolic calcium.致密斑对肾小球滤过的反馈控制：胞质钙的作用
Miner Electrolyte Metab. 1982 Aug;8(2):61-77.
7
Role of macula densa nitric oxide and cGMP in the regulation of tubuloglomerular feedback.致密斑一氧化氮和环磷酸鸟苷在管球反馈调节中的作用。
Kidney Int. 2000 Nov;58(5):2053-60. doi: 10.1111/j.1523-1755.2000.00377.x.
8
On the signal for activation of tubuloglomerular feedback.
J Lab Clin Med. 1982 May;99(5):722-30.
9
Mediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine.肾小球滤过的肾小管-肾小球反馈调节介质：ATP和腺苷。
Acta Physiol (Oxf). 2007 Jan;189(1):3-14. doi: 10.1111/j.1748-1716.2006.01610.x.
10
Macula densa cell signaling.致密斑细胞信号传导
Annu Rev Physiol. 2003;65:481-500. doi: 10.1146/annurev.physiol.65.050102.085730. Epub 2003 Jan 9.
Zotero 插件