解读传感器：致密斑之谜

Making sense of the sensor: mysteries of the macula densa.

作者信息

Blantz R C

机构信息

University of California-San Diego and Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA.

出版信息

Kidney Int. 2006 Sep;70(5):828-30. doi: 10.1038/sj.ki.5001739.

DOI:10.1038/sj.ki.5001739

PMID:16929331

Abstract

Increases in luminal NaCl concentration at the macula densa (MD), the sensing element, activate tubuloglomerular feedback (TGF). MD cell volume increases when increments are isosmotic and shrinks if osmolality increases. This interesting finding introduces additional complexity to the role of the MD in TGF.

摘要

致密斑（MD）作为传感元件，其管腔内氯化钠浓度的升高会激活球管反馈（TGF）。当增量为等渗时，MD细胞体积增加；而当渗透压升高时，细胞体积则会缩小。这一有趣的发现为MD在TGF中的作用增添了额外的复杂性。