Fedorov V N, Sal'nikov E V, Sidorov A V, Bogatushin A V, Fateev M M
Department of Pharmacology, Yaroslavl State Medical Academy.
Bull Exp Biol Med. 2006 Jan;141(1):40-3. doi: 10.1007/s10517-006-0088-1.
Lipophilic inhibitors of angiotensin-converting enzyme increased 6-month survival and/or lifetime of rats with experimental chronic heart failure. These drugs had no effect on the mortality rate of animals with acute decompensation of the disease. beta-Adrenoceptor blockers without intrinsic sympathomimetic activity not only prolonged 6-month survival and lifetime, but also decreased the mortality rate of rats with decompensation of chronic heart failure.
