O'Brien W F, Sternlight D, Torres C, Knuppel R A, Montenegro R
Department of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa 33612.
Prenat Diagn. 1990 Mar;10(3):183-8. doi: 10.1002/pd.1970100308.
The value of determination of maternal serum of alpha-fetoprotein (MSAFP) concentration in the second trimester is well established. In addition to open neural tube defects, pregnancies associated with elevated second-trimester MSAFP have been shown to be at increased risk for a variety of problems, including low birth weight, preterm delivery, and pregnancy-induced hypertension (PIH). We evaluated the potential usefulness of MSAFP in the early third trimester. MSAFP concentration was determined in over 200 women at the time of glucose screening. Results were analysed with regard to gestational age at sampling, maternal weight, race, diabetes, and presence of twins. MSAFP was twice as high in twin gestation, but not affected by race or the presence of diabetes. In contrast to levels in early gestation, third-trimester MSAFP does not appear to be predictive of preterm delivery, low birth weight, or PIH.
孕中期测定母血清甲胎蛋白（MSAFP）浓度的价值已得到充分证实。除开放性神经管缺陷外，孕中期MSAFP升高的妊娠还显示出存在多种问题的风险增加，包括低出生体重、早产和妊娠高血压综合征（PIH）。我们评估了孕晚期早期MSAFP的潜在用途。在葡萄糖筛查时对200多名妇女测定了MSAFP浓度。分析了结果与采样时的孕周、母亲体重、种族、糖尿病和双胞胎情况的关系。双胎妊娠时MSAFP高出两倍，但不受种族或糖尿病存在情况的影响。与妊娠早期水平相反，孕晚期MSAFP似乎不能预测早产、低出生体重或PIH。
