French Craig J
Division of Anaesthesia and Intensive Care, Western Health, Melbourne, VIC, Australia.
Crit Care Resusc. 2006 Sep;8(3):219-22.
Sepsis is a common reason for intensive care unit admission and a leading cause of mortality. Recent prospective randomised controlled trials have shown improved outcomes for patients with severe sepsis. Implementation of these findings into clinical practice has varied. Reasons appear complex but may include regional differences in the epidemiology of sepsis. To improve clinicians' understanding of sepsis, multiple epidemiological studies have been performed in the past 15 years. Differences in study populations and methodology make comparison difficult. After allowing for these differences, it is likely that the percentage of patients with severe sepsis in ICUs is less in Australasia than in many other developed nations. However, the population incidence, mortality, site and causative agent of infection are probably similar. This suggests that treatments and strategies whose efficacy has been demonstrated in other jurisdictions will also be effective in Australasia.
脓毒症是重症监护病房收治患者的常见原因，也是主要的死亡原因。近期的前瞻性随机对照试验表明，严重脓毒症患者的治疗效果有所改善。这些研究结果在临床实践中的应用情况各不相同。原因似乎很复杂，但可能包括脓毒症流行病学的地区差异。为提高临床医生对脓毒症的认识，在过去15年里进行了多项流行病学研究。研究人群和方法的差异使得比较变得困难。考虑到这些差异后，澳大利亚和新西兰重症监护病房中严重脓毒症患者的比例可能低于许多其他发达国家。然而，感染的人群发病率、死亡率、部位和病原体可能相似。这表明，在其他地区已证明有效的治疗方法和策略在澳大利亚和新西兰也将有效。
