Chang Yun Hee, Kim Woong-Han, Lee Jae Young, Kim Soo-Jin, Lee Cheul, Hwang Seong Wook, Sung Si Chan
Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Busan, South Korea.
Pediatr Cardiol. 2006 Sep-Oct;27(5):594-9. doi: 10.1007/s00246-006-1038-4. Epub 2006 Aug 23.
Subaortic stenosis (SAS) in a single ventricle leads to myocardial hypertrophy and compromises Fontan results. Moreover, controversy exists concerning the optimal surgical strategy for relieving SAS. We have applied pulmonary artery banding (PAB) before the Damus-Kaye-Stansel procedure (DKS), and here we analyze factors that influence systemic ventricular compliance. Thirteen patients underwent PAB before DKS. Median PAB duration was 5.5 months (range, 20 days to 17.7 months). Procedures administered concomitantly with DKS were Blalock-Taussig shunt (n = 6), bidirectional cavopulmonary shunt (n = 5), and Fontan operation (n = 2). All survived and were doing well after a median follow-up 2.7 years. Cardiac catheterization before DKS showed that the mean pressure gradient across the systemic ventricular outflow tract and PAB were 20.6 +/- 10.1 and 67.4 +/- 10.2 mmHg, respectively. After DKS, systemic ventricular end diastolic pressure (SVEDP) was significantly correlated with PAB duration (r = 0.65, p = 0.022), but not with PAB or systemic ventricle outflow tract pressure gradients. After DKS, SVEDP decreased or fell to within the range in patients with PAB duration less than 7 months (p < 0.05). Seven patients had a successful Fontan operation, and 6 without risk factors are waiting operation. SVEDP was found to be correlated with PAB duration, and our findings indicate that short-term PAB can be considered a safe option in patients with a single ventricle and SAS.
单心室合并主动脉瓣下狭窄(SAS)会导致心肌肥厚,并影响Fontan手术效果。此外,关于缓解SAS的最佳手术策略存在争议。我们在Damus-Kaye-Stansel手术(DKS)前应用了肺动脉环扎术(PAB),在此分析影响体循环心室顺应性的因素。13例患者在DKS前接受了PAB。PAB的中位持续时间为5.5个月(范围为20天至17.7个月)。与DKS同时进行的手术包括Blalock-Taussig分流术(n = 6)、双向腔肺分流术(n = 5)和Fontan手术(n = 2)。所有患者均存活,中位随访2.7年后情况良好。DKS前的心导管检查显示,体循环心室流出道和PAB的平均压力梯度分别为20.6±10.1和67.4±10.2 mmHg。DKS后,体循环心室舒张末期压力(SVEDP)与PAB持续时间显著相关(r = 0.65,p = 0.022),但与PAB或体循环心室流出道压力梯度无关。DKS后,PAB持续时间小于7个月的患者SVEDP降低或降至正常范围(p < 0.05)。7例患者成功进行了Fontan手术,6例无危险因素的患者等待手术。发现SVEDP与PAB持续时间相关,我们的研究结果表明,短期PAB可被视为单心室合并SAS患者的安全选择。