特发性血小板减少性紫癜患儿未来发生系统性红斑狼疮的危险因素。

Risk factors for future development of systemic lupus erythematosus in children with idiopathic thrombocytopenic purpura.

作者信息

Hazzan Rawi, Mukamel Mashaand, Yacobovich Joanne, Yaniv Isaac, Tamary Hannah

机构信息

Internal Medicine D, Rabin Medical Center, Schneider Children's Medical Center of Israel, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

出版信息

Pediatr Blood Cancer. 2006 Oct 15;47(5 Suppl):657-9. doi: 10.1002/pbc.20970.

DOI:10.1002/pbc.20970

PMID:16933242

Abstract

The risk of later development of systemic lupus erythematosus (SLE) in childhood idiopathic thrombocytopenic purpura (ITP) is currently unknown. We retrospectively evaluated the incidence and risk factors of this complication in 222 children with ITP who were followed for a mean of 4.2+/-4.9 years. During that time 3.6% of the children (8/222) developed SLE; all were females with positive anti-nuclear antibody (ANA), older (12.7+/-3.6 vs. 6.4+/-4.3 years old; P<0.01), and were more likely to have chronic ITP (87.5 vs. 46%; P=0.02), and had high titers of ANA. The majority of children with ITP who had a positive ANA (14/22, 64%) did not develop SLE.

摘要

儿童特发性血小板减少性紫癜（ITP）后期发生系统性红斑狼疮（SLE）的风险目前尚不清楚。我们回顾性评估了222例ITP患儿中这种并发症的发生率和危险因素，这些患儿平均随访了4.2±4.9年。在此期间，3.6%的患儿（8/222）发生了SLE；所有患儿均为抗核抗体（ANA）阳性的女性，年龄较大（12.7±3.6岁 vs. 6.4±4.3岁；P<0.01），更有可能患有慢性ITP（87.5% vs. 46%；P=0.02），且ANA滴度较高。大多数ANA阳性的ITP患儿（14/22，64%）未发生SLE。