Amel Erli, Prathiba D, Kumar Sampath
Department of Pathology, Sri Ramachandra Medical College & Research Institute (DU), Porur, Chennai.
Indian J Pathol Microbiol. 2006 Apr;49(2):239-42.
Coronary atherosclerosis is the most frequent cause of ischemic heart disease. The composition and vulnerability of the atherosclerotic plaque determines the development of acute coronary syndromes. In this study, 224 advanced atherosclerotic plaques were identified from the main coronary arterial branches of 10 autopsy heart specimens. The plaques were classified by American heart association (AHA) and modified American heart association classification. Vulnerability of the plaques and factors influencing vulnerability were assessed. Vulnerable plaques were mostly of Type IV category of AHA classification and of thin cap fibroatheroma type by modified American heart association classification. Inflammation was more frequent and was of a higher grade in vulnerable plaques. Calcification was predominantly of mild grade.
冠状动脉粥样硬化是缺血性心脏病最常见的病因。动脉粥样硬化斑块的组成和易损性决定了急性冠状动脉综合征的发展。在本研究中，从10例尸检心脏标本的主要冠状动脉分支中识别出224个晚期动脉粥样硬化斑块。这些斑块根据美国心脏协会（AHA）分类和改良的美国心脏协会分类进行分类。评估了斑块的易损性及影响易损性的因素。易损斑块大多属于AHA分类的IV型，按照改良的美国心脏协会分类属于薄帽纤维粥样瘤型。易损斑块中炎症更常见且程度更高。钙化主要为轻度。
