Altieri Dario C
Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Curr Opin Cell Biol. 2006 Dec;18(6):609-15. doi: 10.1016/j.ceb.2006.08.015. Epub 2006 Aug 24.
Survivin has aroused keen interest in disparate areas of basic and translational research. This stems from the complexity of a 'survivin network', which appears to intersect multiple pathways of cell division, resistance to apoptosis, surveillance checkpoints and adaptation to unfavorable environments. Such intricacy has also engendered different models for survivin function and its implications. As antagonists of survivin are being evaluated in the clinic, a critical reassessment of the pathway, especially with respect to cell division and cell survival, is now a priority. Building a unifying model to reconcile the differing views on survivin will aid in the design and interpretation of molecularly based clinical trials targeting this network in humans.
存活素已在基础研究和转化研究的不同领域引起了浓厚兴趣。这源于“存活素网络”的复杂性，该网络似乎与细胞分裂、抗凋亡、监测检查点以及适应不利环境等多种途径相互交织。这种错综复杂的情况也催生了关于存活素功能及其影响的不同模型。随着存活素拮抗剂正在临床中进行评估，现在首要任务是对该途径进行批判性重新评估，尤其是在细胞分裂和细胞存活方面。构建一个统一模型以调和对存活素的不同观点，将有助于设计和解释针对人类这个网络的分子基础临床试验。
