Shomali Navid, Suliman Maashi Marwah, Baradaran Behzad, Daei Sorkhabi Amin, Sarkesh Aila, Mohammadi Hamed, Hemmatzadeh Maryam, Marofi Faroogh, Sandoghchian Shotorbani Siamak, Jarahian Mostafa
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Immunol. 2022 Mar 3;13:839945. doi: 10.3389/fimmu.2022.839945. eCollection 2022.
It has been well established that the etiopathogenesis of diverse autoimmune diseases is rooted in the autoreactive immune cells' excessively proliferative state and impaired apoptotic machinery. Survivin is an anti-apoptotic and mitotic factor that has sparked a considerable research interest in this field. Survivin overexpression has been shown to contribute significantly to the development of autoimmune diseases autoreactive immune cell overproliferation and apoptotic dysregulation. Several microRNAs (miRNAs/miRs) have been discovered to be involved in survivin regulation, rendering the survivin-miRNA axis a perspective target for autoimmune disease therapy. In this review, we discuss the role of survivin as an immune regulator and a highly implicated protein in the pathogenesis of autoimmune diseases, the significance of survivin-targeting miRNAs in autoimmunity, and the feasibility of targeting the survivin-miRNA axis as a promising therapeutic option for autoimmune diseases.
多种自身免疫性疾病的发病机制已明确源于自身反应性免疫细胞的过度增殖状态和凋亡机制受损。生存素是一种抗凋亡和有丝分裂因子，在该领域引发了大量研究兴趣。生存素的过表达已被证明对自身免疫性疾病的发展、自身反应性免疫细胞的过度增殖和凋亡失调有显著贡献。已发现几种微小RNA（miRNA/miR）参与生存素的调控，使生存素-miRNA轴成为自身免疫性疾病治疗的一个有前景的靶点。在这篇综述中，我们讨论了生存素作为免疫调节剂和在自身免疫性疾病发病机制中高度相关蛋白的作用、靶向生存素的miRNA在自身免疫中的意义，以及将生存素-miRNA轴作为自身免疫性疾病有前景的治疗选择进行靶向治疗的可行性。
