Vita Marina, Henriksson Marie
Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden.
Semin Cancer Biol. 2006 Aug;16(4):318-30. doi: 10.1016/j.semcancer.2006.07.015. Epub 2006 Aug 3.
Myc expression is deregulated in a wide range of human cancers and is often associated with aggressive, poorly differentiated tumors. The Myc protein is a transcription factor that regulates a variety of cellular processes including cell growth and proliferation, cell-cycle progression, transcription, differentiation, apoptosis, and cell motility. Potential strategies that either inhibit the growth promoting effect of Myc and/or activate its pro-apoptotic function are presently being explored. In this review, we give an overview of Myc activation in human tumors and discuss current strategies aimed at targeting Myc for cancer treatment. Such therapies could have potential in combination with mechanistically different cytotoxic drugs to combat and eradicate tumors cells.
Myc在多种人类癌症中表达失调，常与侵袭性、低分化肿瘤相关。Myc蛋白是一种转录因子，可调节多种细胞过程，包括细胞生长与增殖、细胞周期进程、转录、分化、凋亡和细胞迁移。目前正在探索抑制Myc促生长作用和/或激活其促凋亡功能的潜在策略。在本综述中，我们概述了人类肿瘤中Myc的激活情况，并讨论了目前针对Myc进行癌症治疗的策略。这类疗法可能与机制不同的细胞毒性药物联合使用，以对抗和根除肿瘤细胞。
