Department of Pathology, Dongguk University College of Medicine, Sukjang-dong 707, Kyongju, Kyongbuk 780-714, Republic of Korea.
Pathol Res Pract. 2010 Jan 15;206(1):34-8. doi: 10.1016/j.prp.2009.07.019. Epub 2009 Oct 12.
Helicobacter pylori (H. pylori) colonization induces vigorous innate and specific immune responses; however, the infection is not removed, a state of chronic active gastritis persists for life if untreated. Recent studies have shown that CD4(+) CD25(+) Foxp3-positive regulatory T cells (Tregs) suppress the immune response to H. pylori. Persistent H. pylori-associated gastritis is closely associated with gastric carcinogenesis. We investigated the number of Tregs in the context of H. pylori colonization in chronic gastritis, examined the relationship between it and histopathological findings and compared it with that of gastric dysplasia and adenocarcinoma. This study was based on the analysis of gastric biopsy specimens from 126 cases of H. pylori-associated gastritis, 16 cases of H. pylori-negative gastritis, 17 cases of gastric dysplasia, and 25 cases of gastric adenocarcinoma. The number of Tregs was elevated in H. pylori-associated gastritis, where it was positively correlated with the grade of chronic inflammation and the number of lymphoid follicles. It was significantly elevated in adenocarcinomas compared to chronic gastritis and gastric dysplasia. In summary, the number of Tregs is increased in H. pylori-associated gastritis and gastric cancer.
幽门螺杆菌（H. pylori）定植会引起强烈的固有和特异性免疫反应；然而，如果未经治疗，感染不会被清除，慢性活动性胃炎将持续终生。最近的研究表明，CD4+CD25+Foxp3+调节性 T 细胞（Tregs）抑制了对 H. pylori 的免疫反应。持续的 H. pylori 相关胃炎与胃癌的发生密切相关。我们研究了 Tregs 在慢性胃炎中 H. pylori 定植的情况下的数量，检查了它与组织病理学发现之间的关系，并将其与胃上皮内瘤变和腺癌进行了比较。本研究基于对 126 例 H. pylori 相关胃炎、16 例 H. pylori 阴性胃炎、17 例胃上皮内瘤变和 25 例胃腺癌患者胃活检标本的分析。在 H. pylori 相关胃炎中 Tregs 的数量增加，其与慢性炎症程度和淋巴滤泡数量呈正相关。与慢性胃炎和胃上皮内瘤变相比，腺癌中 Tregs 的数量显著增加。总之，Tregs 在 H. pylori 相关胃炎和胃癌中增加。
