Kwon J Y, Lee Y, Shin J C, Lee J W, Rha J G, Kim S P
Department of Obstetrics and Gynecology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Int J Gynaecol Obstet. 2006 Nov;95(2):115-20. doi: 10.1016/j.ijgo.2006.07.005. Epub 2006 Aug 24.
To examine maternal and fetal outcomes of pregnancy-associated aplastic anemia treated with supportive care.
From January 1995 to December 2004, 14 women newly diagnosed as having pregnancy-associated aplastic anemia were recruited for the study.
Diagnosis was made during the second or third trimester for 11 (78%) of the 14 patients, and 3 of the 8 severe cases of aplastic anemia were diagnosed at initial presentation. All patients had conservative management with transfusions but no specific immunologic or hormonal therapy during pregnancy. Of the 12 women eligible for follow-up, 1 achieved complete remission and 8 achieved partial remission after delivery. The pregnancies progressed uneventfully in most cases.
This study demonstrated favorable maternal and neonatal outcomes with transfusion support alone for pregnancy-associated aplastic anemia.
探讨支持治疗妊娠相关性再生障碍性贫血的母婴结局。
1995年1月至2004年12月，招募14例新诊断为妊娠相关性再生障碍性贫血的女性进行研究。
14例患者中有11例（78%）在妊娠中期或晚期确诊，8例重型再生障碍性贫血患者中有3例在初次就诊时确诊。所有患者在孕期均采用输血保守治疗，未接受特异性免疫或激素治疗。12例 eligible for follow-up的女性中，1例产后完全缓解，8例部分缓解。多数病例妊娠进展顺利。
本研究表明，单纯输血支持治疗妊娠相关性再生障碍性贫血可获得良好的母婴结局。
