Erie Jay C, Raecker Matthew A, Baratz Keith H, Schleck Cathy D, Burke James P, Robertson Dennis M
Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Ophthalmology. 2006 Nov;113(11):2026-32. doi: 10.1016/j.ophtha.2006.05.054. Epub 2006 Aug 28.
To estimate the long-term cumulative risk of retinal detachment (RD) after cataract extraction (CE).
Retrospective cohort study and nested case-control study.
All residents of Olmsted County, Minnesota who had CE from 1980 through 2004 (10 256 CEs in 7137 residents) and were diagnosed subsequently with RD in the same period. Two controls chosen from the primary cataract surgery cohort were matched to each RD case by age, gender, and duration of follow-up.
Cases were identified through the Rochester Epidemiology Project databases. Records were reviewed to confirm case status and ascertain risk factor information. The observed probability of RD after CE was estimated using the Kaplan-Meier method. A cumulative probability ratio of RD after CE was determined by comparing the observed probability of RD and the expected probability of RD in residents without CE. Logistic regression models assessed differences between cases and controls.
Probability of and risk factors associated with RD after CE.
Eighty-two cases of RD were identified. The cumulative probability of RD increased in a nearly linear manner over the 25-year study period. At 1, 5, 10, 15, and 20 years after extracapsular CE (ECCE) and phacoemulsification, cumulative probabilities of RD were 0.27%, 0.71%, 1.23%, 1.58%, and 1.79%, respectively. There was no significant difference in the probability of RD after ECCE when compared with phacoemulsification (P = 0.13). The cumulative probability ratio of RD at 20 years after ECCE and phacoemulsification remained 4.0-fold (95% confidence interval, 2.6-5.4) higher than would be expected in a similar group of residents not undergoing CE (P<0.001). Male gender, younger age, myopia, increased axial length, and posterior capsular tear were associated significantly with RD (P<0.01).
The cumulative risk of RD after ECCE and phacoemulsification is increased for up to 20 years after surgery.
评估白内障摘除术(CE)后视网膜脱离(RD)的长期累积风险。
回顾性队列研究和巢式病例对照研究。
明尼苏达州奥尔姆斯特德县1980年至2004年期间接受CE的所有居民(7137名居民接受了10256次CE),且在同一时期随后被诊断为RD。从原发性白内障手术队列中选取两名对照,按年龄、性别和随访时间与每例RD病例进行匹配。
通过罗切斯特流行病学项目数据库识别病例。查阅记录以确认病例状态并确定危险因素信息。采用Kaplan-Meier方法估计CE后RD的观察概率。通过比较CE后RD的观察概率与未接受CE的居民中RD的预期概率,确定CE后RD的累积概率比。逻辑回归模型评估病例与对照之间的差异。
CE后RD的概率及相关危险因素。
共识别出82例RD病例。在25年的研究期间,RD的累积概率几乎呈线性增加。囊外白内障摘除术(ECCE)和超声乳化术后1、5、10、15和20年,RD的累积概率分别为0.27%、0.71%、1.23%、1.58%和1.79%。ECCE后RD的概率与超声乳化术后相比无显著差异(P = 0.13)。ECCE和超声乳化术后20年RD的累积概率比仍比未接受CE的类似居民组预期高出4.0倍(95%置信区间,2.6 - 5.4)(P<0.001)。男性、年轻、近视、眼轴长度增加和后囊膜破裂与RD显著相关(P<0.01)。
ECCE和超声乳化术后RD的累积风险在术后长达20年内都会增加。