一种源自日本鲨鱼软骨的新型血管生成抑制剂（I）。对肿瘤和胚胎血管生成抑制活性的提取与评估。

A novel angiogenic inhibitor derived from Japanese shark cartilage (I). Extraction and estimation of inhibitory activities toward tumor and embryonic angiogenesis.

作者信息

Oikawa T, Ashino-Fuse H, Shimamura M, Koide U, Iwaguchi T

机构信息

Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.

出版信息

Cancer Lett. 1990 Jun 15;51(3):181-6. doi: 10.1016/0304-3835(90)90100-c.

DOI:10.1016/0304-3835(90)90100-c

PMID:1693543

Abstract

Guanidine extraction and crude fractionation of Japanese shark cartilage by ultrafiltration on a molecular weight basis were conducted and the antiangiogenic activities were assayed as to the inhibitions of tumor and embryonic angiogenesis. Significant inhibition of angiogenesis was found, and there was a linear relationship between the results of the two assays. The inhibitory activities were concentrated in the fraction in the molecular weight range of 103 to 104, and were resistant to heat treatment.

摘要

对日本鲨鱼软骨进行胍提取和基于分子量的超滤粗分级，并针对肿瘤和胚胎血管生成的抑制作用测定抗血管生成活性。发现血管生成受到显著抑制，且两种测定结果之间存在线性关系。抑制活性集中在分子量范围为103至104的级分中，并且对热处理具有抗性。